Gene Symbol | FBLN1 |
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Entrez Gene | 2192 |
Alt Symbol | FBLN, FIBL1 |
Species | Human |
Gene Type | protein-coding |
Description | fibulin 1 |
Other Description | fibulin-1 |
Swissprots | Q9UGR4 Q5TIC4 Q8TBH8 B1AHL4 Q9HBQ5 P37888 P23144 Q9UH41 Q9UC21 P23143 P23142 B0QY42 |
Accessions | AAK82945 CAJ30871 CAJ30872 CAJ30873 CAJ30874 CAJ44949 CBF57602 EAW73385 EAW73386 EAW73387 EAW73388 EAW73389 EAW73390 P23142 AF126110 AAK37822 AF217999 AAG17241 AI092723 AK075460 AK075566 BAC11705 AK093339 AK095988 AK128725 AK300806 BAG62463 AK316291 BAH14662 BC022497 AAH22497 BX403501 BX424750 BX443677 CB852401 DQ894047 ABM84973 U01244 AAB17099 X53741 CAA37770 X53742 CAA37771 X53743 CAA37772 NM_001996 NP_001987 NM_006485 NP_006476 NM_006486 NP_006477 NM_006487 NP_006478 |
Function | Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269|PubMed:11792823, ECO:0000269|PubMed:9393974, ECO:0000269|PubMed:9466671}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix. |
Tissue Specificity | Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells. {ECO:0000269|PubMed:9106159}. |
Fibulin-1 (B-2) - sc-374539 from Santa Cruz Biotechnology
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Fibulin-1 (B-5) - sc-25281 from Santa Cruz Biotechnology
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Fibulin-1 (C-16) - sc-8675 from Santa Cruz Biotechnology
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Fibulin-1 (H-190) - sc-20818 from Santa Cruz Biotechnology
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Fibulin-1 (N-19) - sc-8674 from Santa Cruz Biotechnology
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Fibulin-1 (A-5) - sc-55470 from Santa Cruz Biotechnology
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Anti-Fibulin 1 antibody - ab198187 from Abcam
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Anti-Fibulin 1 antibody - ab192417 from Abcam
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Anti-Fibulin 1 antibody - ab123653 from Abcam
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Anti-Fibulin 1 antibody - ab54652 from Abcam
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Anti-Fibulin 1 antibody - ab67625 from Abcam
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Anti-Fibulin 1 antibody - ab98032 from Abcam
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Anti-Fibulin 1 antibody [EPR10913] - ab175204 from Abcam
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Anti-FBLN1 / Fibulin 1 Antibody (clone MEM-2) - LS-C23661 from LifeSpan Bioscience
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Anti-FBLN1 / Fibulin 1 Antibody (aa621-650, AP) - LS-C214138 from LifeSpan Bioscience
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Anti-FBLN1 / Fibulin 1 Antibody (aa621-650, APC) - LS-C214140 from LifeSpan Bioscience
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Anti-FBLN1 / Fibulin 1 Antibody (aa621-650, Biotin) - LS-C214141 from LifeSpan Bioscience
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Anti-FBLN1 / Fibulin 1 Antibody (aa621-650, Azide-free, HRP) - LS-C214143 from LifeSpan Bioscience
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Anti-FBLN1 / Fibulin 1 Antibody (aa621-650, FITC) - LS-C214142 from LifeSpan Bioscience
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Anti-FBLN1 / Fibulin 1 Antibody (aa621-650, PE) - LS-C214146 from LifeSpan Bioscience
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Anti-FBLN1 / Fibulin 1 Antibody - LS-C294162 from LifeSpan Bioscience
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Anti-FBLN1 / Fibulin 1 Antibody - LS-C294165 from LifeSpan Bioscience
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Anti-FBLN1 / Fibulin 1 Antibody (aa143-192) - LS-C107638 from LifeSpan Bioscience
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Anti-FBLN1 / Fibulin 1 Antibody (aa399-578, Biotin) - LS-C299095 from LifeSpan Bioscience
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Anti-FBLN1 / Fibulin 1 Antibody (aa399-578, Biotin) - LS-C298406 from LifeSpan Bioscience
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