| Gene Symbol | FBLN1 |
|---|---|
| Entrez Gene | 2192 |
| Alt Symbol | FBLN, FIBL1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | fibulin 1 |
| Other Description | fibulin-1 |
| Swissprots | Q9UGR4 Q5TIC4 Q8TBH8 B1AHL4 Q9HBQ5 P37888 P23144 Q9UH41 Q9UC21 P23143 P23142 B0QY42 |
| Accessions | AAK82945 CAJ30871 CAJ30872 CAJ30873 CAJ30874 CAJ44949 CBF57602 EAW73385 EAW73386 EAW73387 EAW73388 EAW73389 EAW73390 P23142 AF126110 AAK37822 AF217999 AAG17241 AI092723 AK075460 AK075566 BAC11705 AK093339 AK095988 AK128725 AK300806 BAG62463 AK316291 BAH14662 BC022497 AAH22497 BX403501 BX424750 BX443677 CB852401 DQ894047 ABM84973 U01244 AAB17099 X53741 CAA37770 X53742 CAA37771 X53743 CAA37772 NM_001996 NP_001987 NM_006485 NP_006476 NM_006486 NP_006477 NM_006487 NP_006478 |
| Function | Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269|PubMed:11792823, ECO:0000269|PubMed:9393974, ECO:0000269|PubMed:9466671}. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix. |
| Tissue Specificity | Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells. {ECO:0000269|PubMed:9106159}. |
Human FBLN1 gene - orb91667 from Biorbyt
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Human FBLN1 cDNA clone(NM_006486.2) - CDFH006636 from Creative Biomart
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Human FBLN1 cDNA clone(NM_006487.2) - CDFH006638 from Creative Biomart
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Human FBLN1 ORF clone(NM_006486.2) - CDCL184190 from Creative Biomart
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Human FBLN1 ORF Clone(NM_001996.3) - CDCR282122 from Creative Biomart
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Human FBLN1 ORF Clone(NM_001996.3) - CDCR282123 from Creative Biomart
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Human FBLN1 ORF Clone(NM_006486.2) - CDCR293003 from Creative Biomart
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Human FBLN1 ORF Clone(NM_006486.2) - CDCR293004 from Creative Biomart
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Human FBLN1 ORF Clone(NM_006486.2) - CDCR293005 from Creative Biomart
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Human FBLN1 ORF Clone(NM_006487.2) - CDCR293006 from Creative Biomart
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Human FBLN1 ORF Clone(NM_006487.2) - CDCR293007 from Creative Biomart
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Mouse FBLN1 ORF clone - CDCL106957 from Creative Biomart
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Mouse FBLN1 ORF clone - CDCL106958 from Creative Biomart
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Human FBLN1 ORF Clone(NM_001996.3) - CDCL163177 from Creative Biomart
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Human FBLN1 ORF Clone(NM_001996.3) - CDCL163178 from Creative Biomart
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Human FBLN1 ORF clone - CDCL106961 from Creative Biomart
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Human FBLN1 ORF clone - CDCL106962 from Creative Biomart
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Human FBLN1 ORF clone - CDCL106963 from Creative Biomart
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Human FBLN1 ORF clone - CDCL106964 from Creative Biomart
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Mouse FBLN1 ORF clone - CDCL106965 from Creative Biomart
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Mouse FBLN1 ORF clone - CDCL106966 from Creative Biomart
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Mouse FBLN1 ORF clone - CDCL106967 from Creative Biomart
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Mouse FBLN1 ORF clone - CDCL106968 from Creative Biomart
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Human FBLN1 ORF clone - CDCL106969 from Creative Biomart
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Human FBLN1 ORF clone - CDCL106970 from Creative Biomart
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