FBLN1
| Gene Symbol | FBLN1 |
|---|---|
| Entrez Gene | 2192 |
| Alt Symbol | FBLN, FIBL1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | fibulin 1 |
| Other Description | fibulin-1 |
| Swissprots | Q9UGR4 Q5TIC4 Q8TBH8 B1AHL4 Q9HBQ5 P37888 P23144 Q9UH41 Q9UC21 P23143 P23142 B0QY42 |
| Accessions | AAK82945 CAJ30871 CAJ30872 CAJ30873 CAJ30874 CAJ44949 CBF57602 EAW73385 EAW73386 EAW73387 EAW73388 EAW73389 EAW73390 P23142 AF126110 AAK37822 AF217999 AAG17241 AI092723 AK075460 AK075566 BAC11705 AK093339 AK095988 AK128725 AK300806 BAG62463 AK316291 BAH14662 BC022497 AAH22497 BX403501 BX424750 BX443677 CB852401 DQ894047 ABM84973 U01244 AAB17099 X53741 CAA37770 X53742 CAA37771 X53743 CAA37772 NM_001996 NP_001987 NM_006485 NP_006476 NM_006486 NP_006477 NM_006487 NP_006478 |
| Function | Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269|PubMed:11792823, ECO:0000269|PubMed:9393974, ECO:0000269|PubMed:9466671}. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix. |
| Tissue Specificity | Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells. {ECO:0000269|PubMed:9106159}. |
Fibulin-1 CRISPR/Cas9 KO Plasmid (h) - sc-401754 from Santa Cruz Biotechnology
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Fibulin-1 HDR Plasmid (h) - sc-401754-HDR from Santa Cruz Biotechnology
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Fibulin-1 Double Nickase Plasmid (h) - sc-401754-NIC from Santa Cruz Biotechnology
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Fibulin-1 Double Nickase Plasmid (h2) - sc-401754-NIC-2 from Santa Cruz Biotechnology
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Fibulin-1 CRISPR Activation Plasmid (h) - sc-401754-ACT from Santa Cruz Biotechnology
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Fibulin-1 CRISPR Activation Plasmid (h2) - sc-401754-ACT-2 from Santa Cruz Biotechnology
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Fibulin-1 Lentiviral Activation Particles (h) - sc-401754-LAC from Santa Cruz Biotechnology
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Fibulin-1 Lentiviral Activation Particles (h2) - sc-401754-LAC-2 from Santa Cruz Biotechnology
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Fibulin-1 siRNA (h) - sc-35372 from Santa Cruz Biotechnology
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Fibulin-1 shRNA Plasmid (h) - sc-35372-SH from Santa Cruz Biotechnology
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Fibulin-1 shRNA (h) Lentiviral Particles - sc-35372-V from Santa Cruz Biotechnology
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Fibulin 1 RNAi - H00002192-R02 from Novus Biologicals
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Fibulin 1 RNAi - H00002192-R04 from Novus Biologicals
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Fibulin 1 RNAi - H00002192-R03 from Novus Biologicals
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Fibulin 1 RNAi - H00002192-R01 from Novus Biologicals
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MISSION® esiRNA - EHU060101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8504 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8504 from Sigma-Aldrich
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FBLN1 siRNA (Human) - CRH1528 from Cohesion Biosciences
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FBLN1 - MBS8220616 from MyBioSource
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Fibulin-1 CRISPR/Cas9 KO Plasmid (h2) - sc-401754-KO-2 from Santa Cruz Biotechnology
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Fibulin-1 HDR Plasmid (h2) - sc-401754-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human FBLN1 (NM_001996.3) - SHH292689 from Creative biogene
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shRNA set against Human FBLN1(NM_006486.2) - SHH050213 from Creative biogene
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shRNA set against Human FBLN1(NM_006487.2) - SHH050247 from Creative biogene
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