Gene Symbol | HIST2H2AC |
---|---|
Entrez Gene | 8338 |
Alt Symbol | H2A, H2A-GL101, H2A/q, H2AFQ |
Species | Human |
Gene Type | protein-coding |
Description | histone cluster 2, H2ac |
Other Description | H2A histone family, member Q|histone 2, H2ac|histone H2A type 2-C|histone H2A-GL101|histone H2A/q|histone IIa |
Swissprots | Q8IUE5 Q6DRA7 Q16777 |
Accessions | AAN59959 AAT68255 CAA41050 CAI12569 EAW53604 Q16777 BC060324 AAH60324 EU446979 ABZ92508 NM_003517 NP_003508 |
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Subcellular Location | Nucleus. Chromosome. |
Top Pathways | Systemic lupus erythematosus, Alcoholism |