| Gene Symbol |
MAP6
|
| Entrez Gene |
4135
|
| Alt Symbol |
MAP6-N, MTAP6, N-STOP, STOP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
microtubule-associated protein 6
|
| Other Description |
CTD-2530H12.7|MAP-6|stable tubule-only polypeptide
|
| Swissprots |
Q6P3T0 Q6ZWB8 A7E2A1 Q96JE9
|
| Accessions |
Q96JE9 AB058781 BAB47507 AK054873 AK096511 AK123340 BAC85586 BC041411 BC063860 AAH63860 BC139780 AAI39781 BC150254 AAI50255 HG503990 XM_006718556 XP_006718619 XM_011545037 XP_011543339 XM_011545038 XP_011543340 XM_011545039 XP_011543341 XR_949931 XR_949932 XR_949933 NM_033063 NP_149052 NM_207577 NP_997460
|
| Function |
Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B. {ECO:0000269|PubMed:24357581}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14692697}. Golgi apparatus {ECO:0000250}. Note=Colocalizes with neurofilament (NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS).
|
| Tissue Specificity |
Expressed in brain (at protein level). Expressed in spinal chord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study). {ECO:0000269|PubMed:14692697, ECO:0000269|PubMed:16624526}.
|
![Western Blot: MAP6 Overexpression Lysate (Adult Normal) [NBP2-05928] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MAP6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6337_MAP6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05928-img0001.jpg)