Gene Symbol | MAP6 |
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Entrez Gene | 4135 |
Alt Symbol | MAP6-N, MTAP6, N-STOP, STOP |
Species | Human |
Gene Type | protein-coding |
Description | microtubule-associated protein 6 |
Other Description | CTD-2530H12.7|MAP-6|stable tubule-only polypeptide |
Swissprots | Q6P3T0 Q6ZWB8 A7E2A1 Q96JE9 |
Accessions | Q96JE9 AB058781 BAB47507 AK054873 AK096511 AK123340 BAC85586 BC041411 BC063860 AAH63860 BC139780 AAI39781 BC150254 AAI50255 HG503990 XM_006718556 XP_006718619 XM_011545037 XP_011543339 XM_011545038 XP_011543340 XM_011545039 XP_011543341 XR_949931 XR_949932 XR_949933 NM_033063 NP_149052 NM_207577 NP_997460 |
Function | Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B. {ECO:0000269|PubMed:24357581}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14692697}. Golgi apparatus {ECO:0000250}. Note=Colocalizes with neurofilament (NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS). |
Tissue Specificity | Expressed in brain (at protein level). Expressed in spinal chord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study). {ECO:0000269|PubMed:14692697, ECO:0000269|PubMed:16624526}. |
STOP (H-8) - sc-137036 from Santa Cruz Biotechnology
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STOP (D-8) - sc-390711 from Santa Cruz Biotechnology
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STOP (E-17) - sc-68834 from Santa Cruz Biotechnology
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STOP (M-300) - sc-68868 from Santa Cruz Biotechnology
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STOP (V-18) - sc-68836 from Santa Cruz Biotechnology
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Anti-MAP6 Antibody (aa132-181) - LS-C135766 from LifeSpan Bioscience
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Anti-MAP6 Antibody (aa177-387) - LS-C295368 from LifeSpan Bioscience
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Anti-MAP6 Antibody (aa360-409) - LS-C170331 from LifeSpan Bioscience
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MAP6 Antibody - NBP1-91503 from Novus Biologicals
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MAP6 Antibody - NBP2-14220 from Novus Biologicals
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MAP6D1 Antibody (L8) - NBP2-29874 from Novus Biologicals
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MAP6 Antibody - NBP2-14221 from Novus Biologicals
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Anti-MAP6 antibody produced in rabbit - HPA039061 from Sigma-Aldrich
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Anti-MAP6 antibody produced in rabbit - SAB2107513 from Sigma-Aldrich
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Anti-MAP6 antibody produced in rabbit - HPA039062 from Sigma-Aldrich
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MAP6 Antibody - middle region (ARP60315_P050) - ARP60315_P050 from Aviva Systems Biology
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MAP6 antibody - N-terminal region (ARP60316_P050) - ARP60316_P050 from Aviva Systems Biology
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MAP6 antibody - 70R-10033 from Fitzgerald
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MAP6 (N-STOP) antibody - AM32779SU-N from Acris Antibodies
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MAP6 Antibody - GWB-MV908H from Genway Biotech
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Polyclonal Antibody to Microtubule Associated Protein 6 (MAP6) - PAB335Mu01 from Uscn Life Science Inc.
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Anti-Stop Antibody - MAB5524 from EMD Millipore
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MAP6, Polyclonal Antibody - MBS5300483 from MyBioSource
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Microtubule Associated Protein 6, Polyclonal Antibody - MBS2028395 from MyBioSource
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MAP6 antibody - TA342905 from Acris Antibodies
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