| Gene Symbol |
NPVF
|
| Entrez Gene |
64111
|
| Alt Symbol |
C7orf9, RFRP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neuropeptide VF precursor
|
| Other Description |
FMRFamide-related peptide|FMRFamide-related peptides|RFamide-related peptide|neuropeptide NPVF|pro-FMRFamide-related neuropeptide VF
|
| Swissprots |
Q7LE27 Q96PI9 A4D164 Q9HCQ7
|
| Accessions |
AAL90458 AAP22339 EAL24237 EAW93830 Q9HCQ7 AB040290 BAB17674 AF330057 AAK94201 AF440392 AAL90453 BC160068 AAI60068 BM714303 NM_022150 NP_071433
|
| Function |
Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide RFRP-1 induces secretion of prolactin in rats. Neuropeptide NPVF blocks morphine- induced analgesia. {ECO:0000269|PubMed:11025660, ECO:0000269|PubMed:20027225}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Isoform 1 is specifically expressed in the retina. Neuropeptides RFRP-1 and NPVF are detected in the hypothalamus. {ECO:0000269|PubMed:11951088, ECO:0000269|PubMed:20027225}.
|
![Western Blot: NPVF Overexpression Lysate (Adult Normal) [NBP2-06457] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NPVF.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10215_NPVF%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06457-img0001.jpg)