Gene Symbol | NPVF |
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Entrez Gene | 64111 |
Alt Symbol | C7orf9, RFRP |
Species | Human |
Gene Type | protein-coding |
Description | neuropeptide VF precursor |
Other Description | FMRFamide-related peptide|FMRFamide-related peptides|RFamide-related peptide|neuropeptide NPVF|pro-FMRFamide-related neuropeptide VF |
Swissprots | Q7LE27 Q96PI9 A4D164 Q9HCQ7 |
Accessions | AAL90458 AAP22339 EAL24237 EAW93830 Q9HCQ7 AB040290 BAB17674 AF330057 AAK94201 AF440392 AAL90453 BC160068 AAI60068 BM714303 NM_022150 NP_071433 |
Function | Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide RFRP-1 induces secretion of prolactin in rats. Neuropeptide NPVF blocks morphine- induced analgesia. {ECO:0000269|PubMed:11025660, ECO:0000269|PubMed:20027225}. |
Subcellular Location | Secreted. |
Tissue Specificity | Isoform 1 is specifically expressed in the retina. Neuropeptides RFRP-1 and NPVF are detected in the hypothalamus. {ECO:0000269|PubMed:11951088, ECO:0000269|PubMed:20027225}. |
RFRP CRISPR/Cas9 KO Plasmid (h) - sc-406767 from Santa Cruz Biotechnology
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RFRP HDR Plasmid (h) - sc-406767-HDR from Santa Cruz Biotechnology
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RFRP Double Nickase Plasmid (h) - sc-406767-NIC from Santa Cruz Biotechnology
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RFRP Double Nickase Plasmid (h2) - sc-406767-NIC-2 from Santa Cruz Biotechnology
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RFRP CRISPR Activation Plasmid (h) - sc-406767-ACT from Santa Cruz Biotechnology
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RFRP CRISPR Activation Plasmid (h2) - sc-406767-ACT-2 from Santa Cruz Biotechnology
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RFRP Lentiviral Activation Particles (h) - sc-406767-LAC from Santa Cruz Biotechnology
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RFRP Lentiviral Activation Particles (h2) - sc-406767-LAC-2 from Santa Cruz Biotechnology
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RFRP siRNA (h) - sc-44797 from Santa Cruz Biotechnology
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RFRP shRNA Plasmid (h) - sc-44797-SH from Santa Cruz Biotechnology
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RFRP shRNA (h) Lentiviral Particles - sc-44797-V from Santa Cruz Biotechnology
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NPVF RNAi - H00064111-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN15476 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15476 from Sigma-Aldrich
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NPVF siRNA (Human) - CRJ1927 from Cohesion Biosciences
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shRNA set against Human Npvf (NM_022150.3) - SHH354512 from Creative biogene
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shRNA set against Human NPVF(NM_022150.3) - SHR019242 from Creative biogene
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RFRP CRISPR/Cas9 KO Plasmid (h2) - sc-406767-KO-2 from Santa Cruz Biotechnology
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RFRP HDR Plasmid (h2) - sc-406767-HDR-2 from Santa Cruz Biotechnology
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Human NPVF siRNA - orb272428 from Biorbyt
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NPVF shRNA Plasmid (Human) - CHJ1927 from Cohesion Biosciences
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NPVF miRNA 3'UTR clone - MiUTR1H-06885 from Creative biogene
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