Gene Symbol | SPDYC |
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Entrez Gene | 387778 |
Alt Symbol | RINGOC, Ringo2 |
Species | Human |
Gene Type | protein-coding |
Description | speedy/RINGO cell cycle regulator family member C |
Other Description | RINGO C|hSpy/Ringo C|rapid inducer of G2/M progression in oocytes C|speedy C|speedy homolog C|speedy protein C |
Swissprots | B2RP32 B7ZMH7 Q5MJ68 |
Accessions | EAW74363 Q5MJ68 AY820305 AAW30396 BC137244 AAI37245 BC137246 AAI37247 BC144548 AAI44549 XM_011545020 XP_011543322 NM_001008778 NP_001008778 |
Function | Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase. {ECO:0000269|PubMed:15611625, ECO:0000269|PubMed:20605920}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:20605920}. Note=Colocalizes with tubulin gamma during interphase. During mitosis, enriched at the spindle poles and the midbody during telophase. |
Tissue Specificity | Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver, placenta and testis. {ECO:0000269|PubMed:15611625}. |
Top Pathways | Progesterone-mediated oocyte maturation, Oocyte meiosis |
Speedy C (P-12) - sc-169406 from Santa Cruz Biotechnology
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Speedy C (C-13) - sc-169404 from Santa Cruz Biotechnology
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Anti-Speedy protein C antibody - ab122597 from Abcam
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Anti-Speedy protein C antibody - N-terminal - ab182498 from Abcam
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Anti-SPDYC Antibody (N-Terminus) - LS-C201909 from LifeSpan Bioscience
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SPDYC Antibody - NBP1-80832 from Novus Biologicals
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Anti-SPDYC antibody produced in rabbit - HPA039891 from Sigma-Aldrich
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SPDYC Antibody - N-terminal region (ARP71664_P050) - ARP71664_P050 from Aviva Systems Biology
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Anti-SPDYC (aa 13-62) polyclonal antibody - DPABH-14046 from Creative Diagnostics
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Anti-SPDYC (aa 29-87) polyclonal antibody - DPABH-20902 from Creative Diagnostics
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Anti-SPDYC monoclonal antibody - DCABH-201526 from Creative Diagnostics
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Speedy C / RINGO C antibody - TA332276 from Acris Antibodies
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ANTI-SPDYC (N-TERM) antibody produced in rabbit - SAB1303958 from Sigma-Aldrich
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Anti-SPDYC Antibody A16984 - A16984 from Boster Bio
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SPDYC Antibody - N-terminal region : Biotin (ARP71664_P050-Biotin) - ARP71664_P050-Biotin from Aviva Systems Biology
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SPDYC Antibody - N-terminal region : FITC (ARP71664_P050-FITC) - ARP71664_P050-FITC from Aviva Systems Biology
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SPDYC Antibody - N-terminal region : HRP (ARP71664_P050-HRP) - ARP71664_P050-HRP from Aviva Systems Biology
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SPDYC antibody - N - terminal region (OAAB11877) - OAAB11877 from Aviva Systems Biology
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Anti-SPDYC Antibody (N-Terminus, HRP) - LS-C478665 from LifeSpan Bioscience
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Anti-SPDYC Antibody (N-Terminus, Biotin) - LS-C478807 from LifeSpan Bioscience
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Anti-SPDYC Antibody (N-Terminus, FITC) - LS-C478664 from LifeSpan Bioscience
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Speedy protein C antibody - orb186195 from Biorbyt
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SPDYC antibody - orb327110 from Biorbyt
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