| Gene Symbol |
SPDYC
|
| Entrez Gene |
387778
|
| Alt Symbol |
RINGOC, Ringo2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
speedy/RINGO cell cycle regulator family member C
|
| Other Description |
RINGO C|hSpy/Ringo C|rapid inducer of G2/M progression in oocytes C|speedy C|speedy homolog C|speedy protein C
|
| Swissprots |
B2RP32 B7ZMH7 Q5MJ68
|
| Accessions |
EAW74363 Q5MJ68 AY820305 AAW30396 BC137244 AAI37245 BC137246 AAI37247 BC144548 AAI44549 XM_011545020 XP_011543322 NM_001008778 NP_001008778
|
| Function |
Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correct localization of the active form of Aurora B in prometaphase. {ECO:0000269|PubMed:15611625, ECO:0000269|PubMed:20605920}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:20605920}. Note=Colocalizes with tubulin gamma during interphase. During mitosis, enriched at the spindle poles and the midbody during telophase.
|
| Tissue Specificity |
Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver, placenta and testis. {ECO:0000269|PubMed:15611625}.
|
| Top Pathways |
Progesterone-mediated oocyte maturation, Oocyte meiosis
|
![Western Blot: SPDYC Overexpression Lysate (Adult Normal) [NBP2-08798] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SPDYC.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/15760_SPDYC%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08798-img0001.jpg)