| Gene Symbol |
HELB
|
| Entrez Gene |
92797
|
| Alt Symbol |
hDHB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
helicase (DNA) B
|
| Other Description |
DNA helicase B
|
| Swissprots |
A8K4C9 Q4G0T2 Q9H7L5 Q8NG08
|
| Accessions |
EAW97165 EAW97166 EAW97167 Q8NG08 AA070301 AF319995 AAM73554 AK290894 BAF83583 BC037946 BC143409 BC143411 BC148592 AAI48593 BC157019 AAI57020 DN997712 XM_005269234 XP_005269291 XR_245966 NM_033647 NP_387467
|
| Function |
Unwinds duplex DNA with 5'-3' polarity. Has single- strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress. {ECO:0000269|PubMed:12181327, ECO:0000269|PubMed:22194613}.
|
| Subcellular Location |
Note=Preferentially during S phase, recruited to chromatin following DNA damage induced by UV irradiation, or camptothecin or hydroxyurea treatment.
|
| Tissue Specificity |
Highly expressed in testis and thymus and weakly in liver, spleen, kidney and brain. {ECO:0000269|PubMed:12181327}.
|
![Western Blot: DNA helicase B Overexpression Lysate (Adult Normal) [NBP2-05870] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DNA helicase B.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9474_DNA%2520helicase%2520B%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05870-img0001.jpg)