| Gene Symbol |
DBF4
|
| Entrez Gene |
10926
|
| Alt Symbol |
ASK, CHIF, DBF4A, ZDBF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DBF4 zinc finger
|
| Other Description |
DBF4 homolog|DBF4 zinc finger A|DBF4-type zinc finger-containing protein 1|activator of S phase kinase|chiffon homolog A|protein DBF4 homolog A|zinc finger, DBF-type containing 1
|
| Swissprots |
A8K954 Q75N01 Q9UBU7 Q75MS6 A4D1D8 Q9Y2M6 O75226
|
| Accessions |
AAS07418 AAS07442 EAL24170 EAW76930 EAW76931 EAW76932 Q9UBU7 AB028069 BAA78326 AB028070 BAA78327 AF160249 AAD41911 AF160876 AAD45357 AK022969 BAG51144 AK292569 BAF85258 AK302010 BAG63412 AK303175 BAH13912 BC014909 BC022811 BC035632 BC036045 AAH36045 BC047693 AAH47693 XM_005250120 XP_005250177 XM_005250121 XP_005250178 XM_005250122 XP_005250179 XM_006715843 XP_006715906 XM_011515764 XP_011514066 XM_011515765 XP_011514067 XR_927343 NM_006716 NP_006707
|
| Function |
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10373557}.
|
| Tissue Specificity |
Highly expressed in testis and thymus. Expressed also in most cancer cells lines. {ECO:0000269|PubMed:10373557}.
|
| Top Pathways |
Cell cycle
|