DBF4

Gene Symbol DBF4
Entrez Gene 10926
Alt Symbol ASK, CHIF, DBF4A, ZDBF1
Species Human
Gene Type protein-coding
Description DBF4 zinc finger
Other Description DBF4 homolog|DBF4 zinc finger A|DBF4-type zinc finger-containing protein 1|activator of S phase kinase|chiffon homolog A|protein DBF4 homolog A|zinc finger, DBF-type containing 1
Swissprots A8K954 Q75N01 Q9UBU7 Q75MS6 A4D1D8 Q9Y2M6 O75226
Accessions AAS07418 AAS07442 EAL24170 EAW76930 EAW76931 EAW76932 Q9UBU7 AB028069 BAA78326 AB028070 BAA78327 AF160249 AAD41911 AF160876 AAD45357 AK022969 BAG51144 AK292569 BAF85258 AK302010 BAG63412 AK303175 BAH13912 BC014909 BC022811 BC035632 BC036045 AAH36045 BC047693 AAH47693 XM_005250120 XP_005250177 XM_005250121 XP_005250178 XM_005250122 XP_005250179 XM_006715843 XP_006715906 XM_011515764 XP_011514066 XM_011515765 XP_011514067 XR_927343 NM_006716 NP_006707
Function Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10373557}.
Tissue Specificity Highly expressed in testis and thymus. Expressed also in most cancer cells lines. {ECO:0000269|PubMed:10373557}.
Top Pathways Cell cycle

Dbf4 CRISPR/Cas9 KO Plasmid (h) - sc-416534 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dbf4 HDR Plasmid (h) - sc-416534-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dbf4 Double Nickase Plasmid (h) - sc-416534-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dbf4 Double Nickase Plasmid (h2) - sc-416534-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dbf4 CRISPR Activation Plasmid (h) - sc-416534-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dbf4 CRISPR Activation Plasmid (h2) - sc-416534-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dbf4 Lentiviral Activation Particles (h) - sc-416534-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dbf4 Lentiviral Activation Particles (h2) - sc-416534-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dbf4 siRNA (h) - sc-37605 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dbf4 shRNA Plasmid (h) - sc-37605-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dbf4 shRNA (h) Lentiviral Particles - sc-37605-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DBF4 RNAi - H00010926-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU109671 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN6943 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6943 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09717 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09717

DBF4 siRNA (Human) - CRH7452 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DBF4 - MBS8225695 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DBF4 (NM_006716.3) - SHH274697 from Creative biogene

Category siRNA
Species Reactivities Human

Human DBF4 siRNA - orb267954 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DBF4 shRNA Plasmid (Human) - CHH7452 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DBF4 miRNA 3'UTR clone - MiUTR1H-02675 from Creative biogene

Species Reactivities Human
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