Gene Symbol | DSG2 |
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Entrez Gene | 1829 |
Alt Symbol | ARVC10, ARVD10, CDHF5, CMD1BB, HDGC |
Species | Human |
Gene Type | protein-coding |
Description | desmoglein 2 |
Other Description | HDGC|cadherin family member 5|desmoglein-2 |
Swissprots | Q14126 Q4KKU6 |
Accessions | CAC81989 EAX01261 EAX01262 Q14126 AK308408 BC014581 BC014584 BC017410 BC022413 BC065747 BC067229 BC071764 BC099655 AAH99655 BC099656 AAH99656 BC099657 AAH99657 BP353513 CN347023 CN395083 DC417739 DR158777 Z26317 CAA81226 NM_001943 NP_001934 |
Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. |
Tissue Specificity | All of the tissues tested and carcinomas. |
Top Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
dsg2 CRISPR/Cas9 KO Plasmid (h) - sc-400957 from Santa Cruz Biotechnology
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dsg2 HDR Plasmid (h) - sc-400957-HDR from Santa Cruz Biotechnology
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dsg2 Double Nickase Plasmid (h) - sc-400957-NIC from Santa Cruz Biotechnology
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dsg2 Double Nickase Plasmid (h2) - sc-400957-NIC-2 from Santa Cruz Biotechnology
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dsg2 CRISPR Activation Plasmid (h) - sc-400957-ACT from Santa Cruz Biotechnology
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dsg2 CRISPR Activation Plasmid (h2) - sc-400957-ACT-2 from Santa Cruz Biotechnology
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dsg2 Lentiviral Activation Particles (h) - sc-400957-LAC from Santa Cruz Biotechnology
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dsg2 Lentiviral Activation Particles (h2) - sc-400957-LAC-2 from Santa Cruz Biotechnology
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dsg2 siRNA (h) - sc-35226 from Santa Cruz Biotechnology
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dsg2 shRNA Plasmid (h) - sc-35226-SH from Santa Cruz Biotechnology
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dsg2 shRNA (h) Lentiviral Particles - sc-35226-V from Santa Cruz Biotechnology
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Desmoglein-2 RNAi - H00001829-R01 from Novus Biologicals
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MISSION® esiRNA - EHU102551 from Sigma-Aldrich
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MISSION® esiRNA - EHU043681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7509 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7509 from Sigma-Aldrich
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DSG2 siRNA (Human) - CRH1278 from Cohesion Biosciences
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DSG2 - MBS827530 from MyBioSource
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shRNA set against Human DSG2 (NM_001943.3) - SHH281277 from Creative biogene
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Human DSG2 siRNA - orb261780 from Biorbyt
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DSG2 shRNA Plasmid (Human) - CHH1278 from Cohesion Biosciences
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DSG2 miRNA 3'UTR clone - MiUTR4H-TG02879 from Creative biogene
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