| Gene Symbol |
RANGAP1
|
| Entrez Gene |
5905
|
| Alt Symbol |
Fug1, RANGAP, SD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ran GTPase activating protein 1
|
| Other Description |
ran GTPase-activating protein 1|segregation distorter homolog|segregation distortion
|
| Swissprots |
P46060 Q96JJ2
|
| Accessions |
EAW60420 EAW60421 EAW60422 EAW60423 EAW60424 P46060 AB058738 BAB47464 AK302222 BAG63578 AK303524 BAG64552 BC004990 AAH04990 BC014044 AAH14044 BC019676 AAH19676 BC041396 AAH41396 BC048990 BM551472 CR456557 CAG30443 CU013157 CAK54588 CU013445 CAK54887 CX872993 DA269460 HY062550 HY251691 X82260 CAA57714 XM_005261695 XP_005261752 XM_005261696 XP_005261753 XM_006724289 XP_006724352 XM_011530293 XP_011528595 XM_011530294 XP_011528596 XM_011530295 XP_011528597 XM_011530296 XP_011528598 XM_011530297 XP_011528599 NM_001278651 NP_001265580 NM_002883 NP_002874
|
| Function |
GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
|
| Subcellular Location |
Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation.
|
| Tissue Specificity |
Highly expressed in brain, thymus and testis. {ECO:0000269|PubMed:8973340}.
|
| Top Pathways |
RNA transport
|