| Gene Symbol | IGF2BP3 |
|---|---|
| Entrez Gene | 10643 |
| Alt Symbol | CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | insulin-like growth factor 2 mRNA binding protein 3 |
| Other Description | IGF-II mRNA-binding protein 3|IGF2 mRNA-binding protein 3|KH domain containing protein overexpressed in cancer|VICKZ family member 3|cancer/testis antigen 98|insulin-like growth factor 2 mRNA-binding protein 3 |
| Swissprots | Q86VB1 Q6MZZ2 Q63HM0 A0A4Z5 O00425 |
| Accessions | CAP40171 EAL24257 EAW93786 EAW93787 O00425 AF117108 AAD09828 BC019258 BC051296 BC065269 AAH65269 BX640800 CAE45883 BX648488 CAH56186 U76705 AAD09223 U97188 AAC35208 XM_006715639 XP_006715702 XM_011515089 XP_011513391 XM_011515090 XP_011513392 XM_011515091 XP_011513393 XM_011515092 XP_011513394 XM_011515093 XP_011513395 NM_006547 NP_006538 |
| Function | RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta- actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942}. |
| Subcellular Location | Nucleus. Cytoplasm. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules. |
| Tissue Specificity | Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines. {ECO:0000269|PubMed:10525192, ECO:0000269|PubMed:12161597, ECO:0000269|PubMed:15644775, ECO:0000269|PubMed:16049158, ECO:0000269|PubMed:16814207, ECO:0000269|PubMed:17192788, ECO:0000269|PubMed:9178771, ECO:0000269|PubMed:9891060}. |