IGF2BP3

Gene Symbol	IGF2BP3
Entrez Gene	10643
Alt Symbol	CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3
Species	Human
Gene Type	protein-coding
Description	insulin-like growth factor 2 mRNA binding protein 3
Other Description	IGF-II mRNA-binding protein 3|IGF2 mRNA-binding protein 3|KH domain containing protein overexpressed in cancer|VICKZ family member 3|cancer/testis antigen 98|insulin-like growth factor 2 mRNA-binding protein 3
Swissprots	Q86VB1 Q6MZZ2 Q63HM0 A0A4Z5 O00425
Accessions	CAP40171 EAL24257 EAW93786 EAW93787 O00425 AF117108 AAD09828 BC019258 BC051296 BC065269 AAH65269 BX640800 CAE45883 BX648488 CAH56186 U76705 AAD09223 U97188 AAC35208 XM_006715639 XP_006715702 XM_011515089 XP_011513391 XM_011515090 XP_011513392 XM_011515091 XP_011513393 XM_011515092 XP_011513394 XM_011515093 XP_011513395 NM_006547 NP_006538
Function	RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta- actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942}.
Subcellular Location	Nucleus. Cytoplasm. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules.
Tissue Specificity	Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines. {ECO:0000269|PubMed:10525192, ECO:0000269|PubMed:12161597, ECO:0000269|PubMed:15644775, ECO:0000269|PubMed:16049158, ECO:0000269|PubMed:16814207, ECO:0000269|PubMed:17192788, ECO:0000269|PubMed:9178771, ECO:0000269|PubMed:9891060}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IMP3 full length protein - ab153106 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human IGF2BP3 Protein - H00010643-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

IMP-3-Antibody-Center-Blocking-Peptide - BP6763c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Igf2bp3 Blocking Peptide - 33R-7697 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

IGF2BP3 / IMP3 - H00010643-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Recombinant Human IGF2BP3 - 230-00640-10 from RayBiotech Category Protein Prices $86.00 Sizes 10 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human IGF2BP3 - 230-00640-50 from RayBiotech Category Protein Prices $174.00 Sizes 50 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human IGF2BP3 - 230-00640-200 from RayBiotech Category Protein Prices $469.00 Sizes 200 µg Source Escherichia coli (E.coli) Species Human

IMP-3 Recombinant Protein - 39-903 from ProSci Category Protein Prices $375.00 Sizes 25 µg Source E. coli Species Human

IGF2BP3 fusion protein - Ag6226 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

IGF2BP3 fusion protein - Ag6349 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human IGF2BP3, GST-tagged - IGF2BP3-14103H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Insulin Like Growth Factor 2 mRNA Binding Protein 3 (IGF2BP3) - RPL617Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Human Insulin-like growth factor 2 mRNA-binding protein 3(IGF2BP3) - CSB-YP011092HU CSB-EP011092HU CSB-BP011092HU CSB-MP011092HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

IGF2BP3 / IMP3 (full length, N-term HIS tag) - TP760798 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

Recombinant Human IGF2BP3 protein, His/T7-tagged - IGF2BP3-16H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human IGF2BP3 protein, His-tagged - IGF2BP3-17H from Creative Biomart Category Protein Source E. coli Species Human

IGF2BP3 Recombinant Protein Antigen - NBP1-84339PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Human IGF2BP3 protein - orb305014 from Biorbyt Category Protein Prices $213.00, $315.00, $655.00 Sizes 10 μg, 50 μg, 200 μg Species Human

IGF2BP3 Peptide, Human - M34GP07481H from Creative Peptides Category Peptide Source Synthetic. Species Human

IGF2BP3 Recombinant Protein (OPCD04177) - OPCD04177 from Aviva Systems Biology Category Protein Source E.coli Species Human

Insulin Like Growth Factor 2 mRNA Binding Protein 3, Recombinant Protein - MBS2030051 from MyBioSource Category Protein Prices $195.00, $410.00, $635.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), Recombinant Protein - MBS1140413 from MyBioSource Category Protein Prices $1,380.00, $1,380.00, $1,595.00, $1,595.00, $2,295.00, $2,295.00, $2,760.00, $2,760.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

IGF2BP3 peptide - orb72844 from Biorbyt Category Peptide

Search more