| Gene Symbol | ADRBK1 |
|---|---|
| Entrez Gene | 156 |
| Alt Symbol | BARK1, BETA-ARK1, GRK2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | adrenergic, beta, receptor kinase 1 |
| Other Description | G-protein coupled receptor kinase 2|beta-ARK-1|beta-adrenergic receptor kinase 1 |
| Swissprots | P25098 B0ZBE1 Q6GTT3 Q13837 |
| Accessions | AAB60689 ACA05909 EAW74581 EAW74582 P25098 AB209588 BAD92825 AI888604 AK131506 BC037963 AAH37963 BC090863 AAH90863 DN989901 DQ891148 ABM82074 DQ894328 ABM85254 M80776 AAA58391 X61157 CAA43470 XM_011544773 XP_011543075 XR_949796 NM_001619 NP_001610 |
| Function | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. {ECO:0000269|PubMed:19306925}. |
| Subcellular Location | Cytoplasm {ECO:0000250|UniProtKB:P21146}. Cell membrane {ECO:0000250|UniProtKB:P21146}. |
| Tissue Specificity | Expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:10085131}. |
| Top Pathways | Endocytosis, Chemokine signaling pathway, Glutamatergic synapse, Morphine addiction |