| Gene Symbol |
ADRBK1
|
| Entrez Gene |
156
|
| Alt Symbol |
BARK1, BETA-ARK1, GRK2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adrenergic, beta, receptor kinase 1
|
| Other Description |
G-protein coupled receptor kinase 2|beta-ARK-1|beta-adrenergic receptor kinase 1
|
| Swissprots |
P25098 B0ZBE1 Q6GTT3 Q13837
|
| Accessions |
AAB60689 ACA05909 EAW74581 EAW74582 P25098 AB209588 BAD92825 AI888604 AK131506 BC037963 AAH37963 BC090863 AAH90863 DN989901 DQ891148 ABM82074 DQ894328 ABM85254 M80776 AAA58391 X61157 CAA43470 XM_011544773 XP_011543075 XR_949796 NM_001619 NP_001610
|
| Function |
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. {ECO:0000269|PubMed:19306925}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250|UniProtKB:P21146}. Cell membrane {ECO:0000250|UniProtKB:P21146}.
|
| Tissue Specificity |
Expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:10085131}.
|
| Top Pathways |
Endocytosis, Chemokine signaling pathway, Glutamatergic synapse, Morphine addiction
|