ADRBK1

Gene Symbol	ADRBK1
Entrez Gene	156
Alt Symbol	BARK1, BETA-ARK1, GRK2
Species	Human
Gene Type	protein-coding
Description	adrenergic, beta, receptor kinase 1
Other Description	G-protein coupled receptor kinase 2|beta-ARK-1|beta-adrenergic receptor kinase 1
Swissprots	P25098 B0ZBE1 Q6GTT3 Q13837
Accessions	AAB60689 ACA05909 EAW74581 EAW74582 P25098 AB209588 BAD92825 AI888604 AK131506 BC037963 AAH37963 BC090863 AAH90863 DN989901 DQ891148 ABM82074 DQ894328 ABM85254 M80776 AAA58391 X61157 CAA43470 XM_011544773 XP_011543075 XR_949796 NM_001619 NP_001610
Function	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. {ECO:0000269|PubMed:19306925}.
Subcellular Location	Cytoplasm {ECO:0000250|UniProtKB:P21146}. Cell membrane {ECO:0000250|UniProtKB:P21146}.
Tissue Specificity	Expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:10085131}.
Top Pathways	Endocytosis, Chemokine signaling pathway, Glutamatergic synapse, Morphine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GRK 2 CRISPR/Cas9 KO Plasmid (h) - sc-400558 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 2 HDR Plasmid (h) - sc-400558-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 2 Double Nickase Plasmid (h) - sc-400558-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 2 Double Nickase Plasmid (h2) - sc-400558-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 2 CRISPR Activation Plasmid (h) - sc-400558-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 2 CRISPR Activation Plasmid (h2) - sc-400558-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 2 Lentiviral Activation Particles (h) - sc-400558-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 2 Lentiviral Activation Particles (h2) - sc-400558-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 2 siRNA (h) - sc-29337 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GRK 2 shRNA Plasmid (h) - sc-29337-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GRK 2 shRNA (h) Lentiviral Particles - sc-29337-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GRK2 RNAi - H00000156-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU047961 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0066 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0065 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0064 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2005 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2005 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08083 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08083

ADRBK1 siRNA (Human) - CRH0110 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ADRBK1 - MBS8221397 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human ADRBK1 (NM_001619.3) - SHH232778 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human ADRBK1(NM_001619.3) - SHG044215 from Creative biogene Category siRNA Species Reactivities Human

ADRBK1 shRNA Plasmid (Human) - CHH0110 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

ADRBK1 miRNA 3'UTR clone - MiUTR1H-00220 from Creative biogene Species Reactivities Human

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