PSEN2

Gene Symbol	PSEN2
Entrez Gene	5664
Alt Symbol	AD3L, AD4, CMD1V, PS2, STM2
Species	Human
Gene Type	protein-coding
Description	presenilin 2
Other Description	AD3LP|AD5|Alzheimer disease 4|E5-1|PS-2|STM-2|presenilin-2
Swissprots	Q96P32 B1AP21 A8K8D4 P49810
Accessions	AAB50054 CDH92547 EAW69796 EAW69797 EAW69798 EAW69799 EAW69800 P49810 AF416718 AAL16812 AI091221 AK292299 BAF84988 AK301143 BAG62735 BC006365 AAH06365 BT006984 AAP35630 DA198818 DA915823 DQ890646 ABM81572 DQ893826 ABM84752 L43964 AAB59557 L44577 AAC42012 U34349 AAC50290 XM_005273199 XP_005273256 XM_011544236 XP_011542538 XR_949149 XR_949150 NM_000447 NP_000438 NM_012486 NP_036618
Function	Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. {ECO:0000269|PubMed:10497236, ECO:0000269|PubMed:10652302}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:8574969}; Multi-pass membrane protein {ECO:0000269|PubMed:8574969}. Golgi apparatus membrane {ECO:0000269|PubMed:8574969}; Multi-pass membrane protein {ECO:0000269|PubMed:8574969}.
Tissue Specificity	Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney. {ECO:0000269|PubMed:8574969}.
Top Pathways	Notch signaling pathway, Alzheimer's disease, Neurotrophin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Presenilin 2 protein fragment - ab114427 from Abcam Category Protein Source Wheat germ Species Human

PSEN2 / Presenilin 2 Antibody Blocking Peptide - LS-E16267 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Presenilin-2 Protein - H00005664-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Presenilin-2-N-Terminal-Peptide - SP2553b from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg

Presenilin-2-N-Terminal-Peptide - SP2553a from Abgent, a WuXi AppTec company Category Peptide Prices $100.00 Sizes 500 µg

Presenilin 2 Blocking Peptide - 33R-9902 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Presenilin-2 - H00005664-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Presenilin-2 - H00005664-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Presenilin-2 control peptide - AP10280CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

PSEN2 fusion protein - ag13628 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PSEN2 - PSEN2-28527TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Presenilin 2 (PS2) - RPB274Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

PS-2 (Presenilin 2) - PAD-53213 from Nordic BioSite Category Protein

PSEN2 Peptide - abx164855 from Abbexa Category Peptide Species Human, Rat

Presenilin-2 (PSEN2), Recombinant Protein - MBS950799 from MyBioSource Category Protein Prices $1,375.00, $1,835.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Presenilin-2-PSEN2-Antibody-N-term-Blocking-peptide - BP6232a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Presenilin-2-PSEN2-Antibody-N-term-Blocking-peptide - BP6305b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Presenilin-2-PSEN2-Antibody-C-term-Blocking-peptide - BP6305a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Presenilin-21-PSEN2PSEN1-Antibody-N-term-Blocking-peptide - BP6304c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PSEN2-Blocking-Peptide-N-term - BP20599a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PSEN2Presenilin-2-CTF-subunit-Blocking-Peptide-C-term - BP20576c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PSEN2 Peptide, Human - M34GP12561H from Creative Peptides Category Peptide Source Synthetic. Species Human

PSEN2 Antibody - SH-A14857 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human, Mouse

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