PSEN2

Gene Symbol PSEN2
Entrez Gene 5664
Alt Symbol AD3L, AD4, CMD1V, PS2, STM2
Species Human
Gene Type protein-coding
Description presenilin 2
Other Description AD3LP|AD5|Alzheimer disease 4|E5-1|PS-2|STM-2|presenilin-2
Swissprots Q96P32 B1AP21 A8K8D4 P49810
Accessions AAB50054 CDH92547 EAW69796 EAW69797 EAW69798 EAW69799 EAW69800 P49810 AF416718 AAL16812 AI091221 AK292299 BAF84988 AK301143 BAG62735 BC006365 AAH06365 BT006984 AAP35630 DA198818 DA915823 DQ890646 ABM81572 DQ893826 ABM84752 L43964 AAB59557 L44577 AAC42012 U34349 AAC50290 XM_005273199 XP_005273256 XM_011544236 XP_011542538 XR_949149 XR_949150 NM_000447 NP_000438 NM_012486 NP_036618
Function Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. {ECO:0000269|PubMed:10497236, ECO:0000269|PubMed:10652302}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:8574969}; Multi-pass membrane protein {ECO:0000269|PubMed:8574969}. Golgi apparatus membrane {ECO:0000269|PubMed:8574969}; Multi-pass membrane protein {ECO:0000269|PubMed:8574969}.
Tissue Specificity Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney. {ECO:0000269|PubMed:8574969}.
Top Pathways Notch signaling pathway, Alzheimer's disease, Neurotrophin signaling pathway

Presenilin 2 Antibody - 2192 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from human (293 and HeLa), mouse (NIH/3T3 and L929) and rat (C6 and PC12) cell lines, using Presenilin 2 Antibody.

Presenilin 2 (D30G3) Rabbit mAb - 9979 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D30G3
Western blot analysis of extracts from Presenilin 1 (-/-) and Presenilin 2 (-/-) MEF cells using Presenilin 2 (D30G3) Rabbit mAb (upper) and Presenilin 1 (D39D1) Rabbit mAb #5643 (lower). (Presenilin 1 (-/-) and Presenilin 2 (-/-) MEF cells were kindly provided by Dr. Bart De Strooper, K.U.Leuven, Belgium).

Presenilin 2 (B-7) - sc-393758 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Presenilin 2 (B-7): sc-393758. Western blot analysis of Presenilin 2 expression in non-transfected: sc-117752 (A) and human Presenilin 2 transfected: sc-172789 (B) 293T whole cell lysates.

Presenilin 2 (C-20) - sc-1456 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Presenilin 2 (C-20): sc-1456. Western blot analysis of aggregated Presenilin 2 expression in IMR-32 (A) and HeLa (B) whole cell lysates.

Presenilin 2 (N-20) - sc-1457 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Presenilin 2 (N-20): sc-1457. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

Presenilin 2 (H-76) - sc-7861 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Presenilin 2 (H-76): sc-7861. Western blot analysis of Presenilin 2 expression in non-transfected: sc-117752 (A) and human Presenilin 2 transfected: sc-172789 (B) 293T whole cell lysates.

Anti-Presenilin 2 (phospho S327) antibody [EP2613Y] - ab76114 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2613Y
All lanes : Anti-Presenilin 2 (phospho S327) antibody [EP2613Y] (ab76114) at 1/5000 dilutionLane 1 : HeLa cell lysates un-treatedLane 2 : HeLa cell lysates treated with APLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Presenilin 2 (phospho S330) antibody [EP2614] - ab109456 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2614
All lanes : Anti-Presenilin 2 (phospho S330) antibody [EP2614] (ab109456) at 1/5000 dilutionLane 1 : HeLa cell lysate untreated with with Alkaline PhosphataseLane 2 : HeLa cell lysate treated with Alkaline PhosphataseLysates/proteins at 10 µg per lane.SecondaryHRP-labelled goat anti-rabbit at 1/2000 dilution

Anti-Presenilin 2 antibody - ab106351 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Presenilin 2 antibody (ab106351) at 1 µg/mlLane 1 : Rat brain tissue lysateLane 2 : Rat brain tissue lysateLane 3 : MCF7 whole cell lysateLane 4 : HeLa whole cell lysateLane 5 : SMMC whole cell lysateLane 6 : CEM whole cell lysate

Anti-Presenilin 2 antibody - ab16245 from Abcam

Prices $370.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal

Anti-Presenilin 2 antibody - ab7301 from Abcam

Prices $370.00
Sizes 50 µl
Host Goat
Clonality Polyclonal

Anti-Presenilin 2 antibody [198C679.2.1] - ab13926 from Abcam

Prices $359.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 198C679.2.1

Anti-Presenilin 2 antibody [APS 21] - ab15548 from Abcam

Prices $385.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone APS 21
Immunocytochemistry/Immunofluorescence analysis of NCI-H460 cells labeling Presenilin 2 (green) with ab15548 at 1/100. F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue). Cells were fixed with formaldehyde and incubated with the primary antibody overnight at 4°C. A DyLight 488-conjugated secondary antibody was used. 60X magnification. Right - negative control.

Anti-Presenilin 2 antibody [APS 26] - ab15549 from Abcam

Prices $387.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone APS 26
Immunocytochemistry/Immunofluorescence analysis of HeLa cells labeling Presenilin 2 (green) with ab15549 at 1/20. F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue). Cells were fixed with formaldehyde and incubated with the primary antibody overnight at 4°C. A DyLight 488-conjugated secondary antibody was used. 60X magnification. Right - negative control.

Anti-Presenilin 2 antibody [EP1515Y] - ab51249 from Abcam

Prices $99.00, $395.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1515Y
Immunofluorescent analysis of 100% methanol-fixed, 0.1% Triton X-100 permeabilized JAR (Human placenta choriocarcinoma cell line) cells labeling Presenilin with ab51249 at 1/250 dilution, followed by Anti-rabbit Alexa Fluor® 488 (ab150077) secondary antibody at 1/500 dilution (green). Confocal image showing cytoplasm staining on JAR cells. The nuclear counter stain is DAPI (blue). Tubulin is detected with ab7291 (anti-Tubulin mouse mAb) at 1/1000 dilution and Anti-Mouse AlexaFluor® 594 (ab150120) at 1/500 dilution (red).The negative controls are as follows:-ve control 1: ab51249 at 1/250 dilution followed by Anti-Mouse AlexaFluor® 594 (ab150120) at 1/500 dilution.-ve control 2: ab7291 (anti-Tubulin mouse mAb) at 1/1000 dilution followed by Anti-Rabbit Alexa Fluor® 488 (ab150077) at 1/500 dilution.

Anti-Presenilin 2 antibody [MM0516-7F8] - ab89910 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0516-7F8

Anti-Presenilin 2 antibody - C-terminal - ab191225 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Presenilin 2 antibody - C-terminal (ab191225) at 1/1000 dilutionLane 1 : HeLa cell line lysateLane 2 : MCF7 cell line lysateLysates/proteins at 35 µg per lane.Secondarygoat anti-rabbit IgG H&L(HRP) at 1/5000 dilution

Anti-Presenilin 2 antibody - N-terminal - ab60121 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Presenilin 2 antibody - N-terminal (ab60121) at 1/50 dilution + Mouse kidney tissue lysate at 35 µg

Anti-Presenilin 2 antibody - N-terminal - ab200092 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-Presenilin 2 antibody - N-terminal (ab200092) at 1/1000 dilutionLane 1 : Mouse thymus total cell extractLane 2 : HeLa total cell extractLane 3 : Jurkat total cell extract

Anti-PSEN2 / Presenilin 2 Antibody (aa275-325) - LS-C290984 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Presenilin-2 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-Presenilin-2 antibody used for IP at 6 ug per reaction. Presenilin-2 was also immunoprecipitated by rabbit anti-Presenilin-2 antibody BL15974. For blotting immunoprecipitated Presenilin-2, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-PSEN2 / Presenilin 2 Antibody (C-Terminus, clone EP1515Y) - LS-C49941 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1515Y
IHC of paraffin-embedded human kidney using anti-Presenilin 2 antibody.

Anti-PSEN2 / Presenilin 2 Antibody (aa32-65) - LS-C344240 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysate from HeLa cell line with PSEN2 (Presenilin-2 NTF subunit) Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35 ug.

Anti-PSEN2 / Presenilin 2 Antibody (aa401-445) - LS-C344220 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical of paraffin-embedded H.heart section using PSEN2 (Presenilin-2 CTF subunit) Antibody. Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.

Anti-PSEN2 / Presenilin 2 Antibody (aa50-65) - LS-C3162 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PSEN2 / Presenilin 2 Antibody (aa31-47) - LS-C11498 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µl
Host Goat
Clonality Polyclonal
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