Gene Symbol |
Fermt3
|
Entrez Gene |
108101
|
Alt Symbol |
C79673, Kindlin3
|
Species |
Mouse
|
Gene Type |
protein-coding
|
Description |
fermitin family homolog 3 (Drosophila)
|
Other Description |
fermitin family homolog 3|unc-112-related protein 2
|
Swissprots |
Q8K1B8
|
Accessions |
EDL33286 EDL33287 Q8K1B8 AK090332 AK142912 AK149737 AK158357 AK161025 AK169682 BAE41302 BC025119 AAH25119 BC032204 AAH32204 BC066803 AAH66803 XM_006526593 XP_006526656 XM_006526594 XP_006526657 XM_006526595 XP_006526658 NM_153795 NP_722490
|
Function |
Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). {ECO:0000269|PubMed:18278053, ECO:0000269|PubMed:18662549, ECO:0000269|PubMed:19234461}.
|
Subcellular Location |
Cell projection, podosome {ECO:0000269|PubMed:16876785}. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.
|
Tissue Specificity |
Specifically expressed in hematopoietic cells. {ECO:0000269|PubMed:16876785}.
|