Gene Symbol | Fermt3 |
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Entrez Gene | 108101 |
Alt Symbol | C79673, Kindlin3 |
Species | Mouse |
Gene Type | protein-coding |
Description | fermitin family homolog 3 (Drosophila) |
Other Description | fermitin family homolog 3|unc-112-related protein 2 |
Swissprots | Q8K1B8 |
Accessions | EDL33286 EDL33287 Q8K1B8 AK090332 AK142912 AK149737 AK158357 AK161025 AK169682 BAE41302 BC025119 AAH25119 BC032204 AAH32204 BC066803 AAH66803 XM_006526593 XP_006526656 XM_006526594 XP_006526657 XM_006526595 XP_006526658 NM_153795 NP_722490 |
Function | Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). {ECO:0000269|PubMed:18278053, ECO:0000269|PubMed:18662549, ECO:0000269|PubMed:19234461}. |
Subcellular Location | Cell projection, podosome {ECO:0000269|PubMed:16876785}. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells. |
Tissue Specificity | Specifically expressed in hematopoietic cells. {ECO:0000269|PubMed:16876785}. |
Recombinant Mouse Fermitin family homolog 3(Fermt3) - CSB-YP810365MO CSB-EP810365MO CSB-BP810365MO CSB-MP810365MO from Cusabio
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Fermitin family homolog 3 (Fermt3), Recombinant Protein - MBS1345073 from MyBioSource
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