Gene Symbol | Fermt3 |
---|---|
Entrez Gene | 108101 |
Alt Symbol | C79673, Kindlin3 |
Species | Mouse |
Gene Type | protein-coding |
Description | fermitin family homolog 3 (Drosophila) |
Other Description | fermitin family homolog 3|unc-112-related protein 2 |
Swissprots | Q8K1B8 |
Accessions | EDL33286 EDL33287 Q8K1B8 AK090332 AK142912 AK149737 AK158357 AK161025 AK169682 BAE41302 BC025119 AAH25119 BC032204 AAH32204 BC066803 AAH66803 XM_006526593 XP_006526656 XM_006526594 XP_006526657 XM_006526595 XP_006526658 NM_153795 NP_722490 |
Function | Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). {ECO:0000269|PubMed:18278053, ECO:0000269|PubMed:18662549, ECO:0000269|PubMed:19234461}. |
Subcellular Location | Cell projection, podosome {ECO:0000269|PubMed:16876785}. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells. |
Tissue Specificity | Specifically expressed in hematopoietic cells. {ECO:0000269|PubMed:16876785}. |
Kindlin-3 CRISPR/Cas9 KO Plasmid (m) - sc-430812 from Santa Cruz Biotechnology
|
||||||||
Kindlin-3 HDR Plasmid (m) - sc-430812-HDR from Santa Cruz Biotechnology
|
||||||||
Kindlin-3 Double Nickase Plasmid (m) - sc-430812-NIC from Santa Cruz Biotechnology
|
||||||||
Kindlin-3 Double Nickase Plasmid (m2) - sc-430812-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Kindlin-3 CRISPR Activation Plasmid (m) - sc-430812-ACT from Santa Cruz Biotechnology
|
||||||||
Kindlin-3 CRISPR Activation Plasmid (m2) - sc-430812-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Kindlin-3 Lentiviral Activation Particles (m) - sc-430812-LAC from Santa Cruz Biotechnology
|
||||||||
Kindlin-3 Lentiviral Activation Particles (m2) - sc-430812-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Kindlin-3 siRNA (m) - sc-146483 from Santa Cruz Biotechnology
|
||||||||
Kindlin-3 shRNA Plasmid (m) - sc-146483-SH from Santa Cruz Biotechnology
|
||||||||
Kindlin-3 shRNA (m) Lentiviral Particles - sc-146483-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EMU012131 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN31325 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31325 from Sigma-Aldrich
|
||||||||
FERMT3 siRNA (Mouse) - CRN0915 from Cohesion Biosciences
|
||||||||
FERMT3 - MBS8223246 from MyBioSource
|
||||||||
shRNA set against Mouse FERMT3 (NM_153795.2) - SHH294129 from Creative biogene
|
||||||||
Mouse FERMT3 siRNA - orb290390 from Biorbyt
|
||||||||
FERMT3 shRNA Plasmid (Mouse) - CHN0915 from Cohesion Biosciences
|