| Gene Symbol |
ZNF423
|
| Entrez Gene |
23090
|
| Alt Symbol |
Ebfaz, JBTS19, NPHP14, OAZ, Roaz, ZFP423, Zfp104
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger protein 423
|
| Other Description |
OLF-1/EBF associated zinc finger|Smad- and Olf-interacting zinc finger protein|early B-cell factor associated zinc finger protein|hOAZ|olf1/EBF-associated zinc finger protein
|
| Swissprots |
O94860 Q76N04 Q9NZ13 Q2M1K9
|
| Accessions |
EAW82735 Q2M1K9 AB018303 BAA34480 AF221712 AAF28354 AK027479 BAG51329 AK304829 BAH14263 AK309835 AK314742 AW022965 BC112315 AAI12316 BC112317 AAI12318 BU733621 CD626621 CN396210 HQ258687 ADR83438 XM_005255856 XP_005255913 XM_005255857 XP_005255914 XM_006721171 XP_006721234 XM_011522962 XP_011521264 NM_001271620 NP_001258549 NM_015069 NP_055884
|
| Function |
Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. {ECO:0000269|PubMed:10660046}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10660046}.
|
| Tissue Specificity |
Expressed in brain, lung, skeletal muscle, heart, pancreas and kidney but not liver or placenta. Also expressed in aorta, ovary, pituitary, small intestine, fetal brain, fetal kidney and, within the adult brain, in the substantia nigra, medulla, amygdala, thalamus and cerebellum. {ECO:0000269|PubMed:10660046}.
|