ZNF423
| Gene Symbol | ZNF423 |
|---|---|
| Entrez Gene | 23090 |
| Alt Symbol | Ebfaz, JBTS19, NPHP14, OAZ, Roaz, ZFP423, Zfp104 |
| Species | Human |
| Gene Type | protein-coding |
| Description | zinc finger protein 423 |
| Other Description | OLF-1/EBF associated zinc finger|Smad- and Olf-interacting zinc finger protein|early B-cell factor associated zinc finger protein|hOAZ|olf1/EBF-associated zinc finger protein |
| Swissprots | O94860 Q76N04 Q9NZ13 Q2M1K9 |
| Accessions | EAW82735 Q2M1K9 AB018303 BAA34480 AF221712 AAF28354 AK027479 BAG51329 AK304829 BAH14263 AK309835 AK314742 AW022965 BC112315 AAI12316 BC112317 AAI12318 BU733621 CD626621 CN396210 HQ258687 ADR83438 XM_005255856 XP_005255913 XM_005255857 XP_005255914 XM_006721171 XP_006721234 XM_011522962 XP_011521264 NM_001271620 NP_001258549 NM_015069 NP_055884 |
| Function | Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. {ECO:0000269|PubMed:10660046}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:10660046}. |
| Tissue Specificity | Expressed in brain, lung, skeletal muscle, heart, pancreas and kidney but not liver or placenta. Also expressed in aorta, ovary, pituitary, small intestine, fetal brain, fetal kidney and, within the adult brain, in the substantia nigra, medulla, amygdala, thalamus and cerebellum. {ECO:0000269|PubMed:10660046}. |
OAZ CRISPR/Cas9 KO Plasmid (h) - sc-403765 from Santa Cruz Biotechnology
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OAZ HDR Plasmid (h) - sc-403765-HDR from Santa Cruz Biotechnology
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OAZ Double Nickase Plasmid (h) - sc-403765-NIC from Santa Cruz Biotechnology
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OAZ Double Nickase Plasmid (h2) - sc-403765-NIC-2 from Santa Cruz Biotechnology
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OAZ CRISPR Activation Plasmid (h) - sc-403765-ACT from Santa Cruz Biotechnology
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OAZ CRISPR Activation Plasmid (h2) - sc-403765-ACT-2 from Santa Cruz Biotechnology
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OAZ Lentiviral Activation Particles (h) - sc-403765-LAC from Santa Cruz Biotechnology
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OAZ Lentiviral Activation Particles (h2) - sc-403765-LAC-2 from Santa Cruz Biotechnology
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OAZ siRNA (h) - sc-38144 from Santa Cruz Biotechnology
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OAZ shRNA Plasmid (h) - sc-38144-SH from Santa Cruz Biotechnology
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OAZ shRNA (h) Lentiviral Particles - sc-38144-V from Santa Cruz Biotechnology
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ZNF423 RNAi - H00023090-R01 from Novus Biologicals
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MISSION® esiRNA - EHU023111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23443 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23443 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06207 from Sigma-Aldrich
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ZNF423 siRNA (Human) - CRH7989 from Cohesion Biosciences
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ZNF423 - MBS8223565 from MyBioSource
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shRNA set against Human ZNF423 (NM_015069.3) - SHH453900 from Creative biogene
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ZNF423 shRNA Plasmid (Human) - CHH7989 from Cohesion Biosciences
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ZNF423 miRNA 3'UTR clone - MiUTR3H-06908 from Creative biogene
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