DIAPH3

Gene Symbol DIAPH3
Entrez Gene 81624
Alt Symbol AN, AUNA1, DIA2, DRF3, NSDAN, diap3, mDia2
Species Human
Gene Type protein-coding
Description diaphanous-related formin 3
Other Description diaphanous homolog 3|diaphanous-related formin-3|protein diaphanous homolog 3
Swissprots A2A3B9 Q2KPB6 Q5JTP8 Q6NUP0 A2A3B8 Q86VS4 Q5T2S7 Q18PA1 Q9NSV4 Q3ZK23 Q18P99 Q18PA0 Q5XKF6 Q8NAV4 A2A3C0 Q6MZF0
Accessions EAW52069 EAW52070 EAW52071 EAW52072 EAW52073 EAW52074 Q9NSV4 AB244756 BAE96350 AB244757 BAE96351 AB244758 BAE96352 AK092024 BAC03793 AK298509 BAG60715 AK307652 AK316474 BAH14845 AL137718 CAB70890 AY750055 AAW73254 AY818645 AAW78862 BC034952 AAH34952 BC041395 AAH41395 BC048963 AAH48963 BC068504 AAH68504 BF979672 BG203073 BX649186 CAE46204 CA310418 XM_006719876 XP_006719939 XM_011535258 XP_011533560 XM_011535259 XP_011533561 XM_011535260 XP_011533562 XM_011535261 XP_011533563 XM_011535262 XP_011533564 XM_011535263 XP_011533565 XM_011535264 XP_011533566 XM_011535265 XP_011533567 XR_941672 NM_001042517 NP_001035982 NM_001258366 NP_001245295 NM_001258367 NP_001245296 NM_001258368 NP_001245297 NM_001258369 NP_001245298 NM_001258370 NP_001245299 NM_030932 NP_112194
Function Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:18755006, ECO:0000269|PubMed:19457867}. Note=During mitosis, co-localizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis.
Top Pathways Regulation of actin cytoskeleton

DIAPH3 (E-18) - sc-68066 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

DIAPH3 (H-42) - sc-135261 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

DIAPH3 (F-20) - sc-68067 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-DIAPH3 antibody - ab189373 from Abcam

Prices $407.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human adrenal tissue, labeling DIAPH3 using ab189373 at 10 µg/ml.

Anti-DIAPH3 antibody - ab172701 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-DIAPH3 antibody (ab172701) at 1 µg/mlLane 1 : DIAPH3 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-mouse HRP Conjugate at 1/2500 dilution

Anti-DIAPH3 antibody - ab172722 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DIAPH3 antibody (ab172722) at 1 µg/mlLane 1 : DIAPH3 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-DIAPH3 antibody - ab77678 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-DIAPH3 antibody (ab77678) at 1/500 dilution + Recombinant fragment of human DIAPH3 at 0.2 µgSecondaryGoat anti-Mouse IgG (H&L)-HRP at 1/5000 dilutiondeveloped using the ECL technique

Anti-DIAPH3 antibody - ab129668 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DIAPH3 antibody (ab129668) at 1/100 dilution + NCI-H460 cell line lysate at 35 µg

Anti-DIAPH3 / MDIA2 Antibody (aa1081-1091) - LS-C54719 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-DIAPH3 / MDIA2 Antibody (aa1060-1090, AP) - LS-C234590 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIAPH3 / MDIA2 Antibody (aa1060-1090, APC) - LS-C234591 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIAPH3 / MDIA2 Antibody (aa1060-1090, Biotin) - LS-C234592 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIAPH3 / MDIA2 Antibody (aa1060-1090, PE) - LS-C234594 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIAPH3 / MDIA2 Antibody (aa1060-1090, FITC) - LS-C234593 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIAPH3 / MDIA2 Antibody (aa1061-1090) - LS-C167413 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
DIAPH3 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The DIAPH3 antibody detected the DIAPH3 protein (arrow).

Anti-DIAPH3 / MDIA2 Antibody (aa632-730) - LS-C307254 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DIAPH3 / MDIA2 Antibody (aa1060-1090, Azide-free, HRP) - LS-C249832 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIAPH3 / MDIA2 Antibody (aa1060-1090) - LS-C329468 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIAPH3 / MDIA2 Antibody - LS-C310132 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DIAPH3 / MDIA2 Antibody (N-Terminus) - LS-C345127 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of DIAPH3 Antibody with human MCF7 Whole Cell lysate.

Anti-DIAPH3 / MDIA2 Antibody IHC-plus™ - LS-B8892 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-DIAPH3 / MDIA2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

DIAPH3 Antibody - NBP1-89099 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: DIAPH3 Antibody [NBP1-89099] - Staining of human kidney shows strong cytoplasmic positivity, with a granular pattern in cells in tubules.

DIAPH3 Antibody - H00081624-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: DIAPH3 Antibody [H00081624-B01] - analysis of DIAPH3 expression in transfected 293T cell line by DIAPH3 MaxPab polyclonal antibody. Lane 1: DIAPH3 transfected lysate (98.10 KDa). Lane 2: Non-transfected lysate.

DIAPH3 Antibody - H00081624-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

DIAPH3 Antibody - H00081624-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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