DIAPH3

Gene Symbol	DIAPH3
Entrez Gene	81624
Alt Symbol	AN, AUNA1, DIA2, DRF3, NSDAN, diap3, mDia2
Species	Human
Gene Type	protein-coding
Description	diaphanous-related formin 3
Other Description	diaphanous homolog 3|diaphanous-related formin-3|protein diaphanous homolog 3
Swissprots	A2A3B9 Q2KPB6 Q5JTP8 Q6NUP0 A2A3B8 Q86VS4 Q5T2S7 Q18PA1 Q9NSV4 Q3ZK23 Q18P99 Q18PA0 Q5XKF6 Q8NAV4 A2A3C0 Q6MZF0
Accessions	EAW52069 EAW52070 EAW52071 EAW52072 EAW52073 EAW52074 Q9NSV4 AB244756 BAE96350 AB244757 BAE96351 AB244758 BAE96352 AK092024 BAC03793 AK298509 BAG60715 AK307652 AK316474 BAH14845 AL137718 CAB70890 AY750055 AAW73254 AY818645 AAW78862 BC034952 AAH34952 BC041395 AAH41395 BC048963 AAH48963 BC068504 AAH68504 BF979672 BG203073 BX649186 CAE46204 CA310418 XM_006719876 XP_006719939 XM_011535258 XP_011533560 XM_011535259 XP_011533561 XM_011535260 XP_011533562 XM_011535261 XP_011533563 XM_011535262 XP_011533564 XM_011535263 XP_011533565 XM_011535264 XP_011533566 XM_011535265 XP_011533567 XR_941672 NM_001042517 NP_001035982 NM_001258366 NP_001245295 NM_001258367 NP_001245296 NM_001258368 NP_001245297 NM_001258369 NP_001245298 NM_001258370 NP_001245299 NM_030932 NP_112194
Function	Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:18755006, ECO:0000269|PubMed:19457867}. Note=During mitosis, co-localizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis.
Top Pathways	Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DIAPH3 293T Cell Transient Overexpression Lysate(Denatured) - H00081624-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

DIAPH3 overexpression lysate - LY410648 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

DIAPH3 293 Cell Lysate - 405425 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Drosophila

DIAPH3 Overexpression Lysate (Native) - NBL1-09883 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

DIAPH3 Overexpression Lysate (Native) - NBP2-08380 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

DIAPH3 Overexpression Lysate (Native) - NBP2-09237 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

DIAPH3 Over-expression Lysate Product - GWB-919FFC from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

DIAPH3 Overexpression Lysate (Denatured) - H00081624-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human DIAPH3 Knockdown Stable Cell Line - CSC-DC004303 from Creative biogene Category Cell Line Species Human

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