DIAPH3
| Gene Symbol | DIAPH3 |
|---|---|
| Entrez Gene | 81624 |
| Alt Symbol | AN, AUNA1, DIA2, DRF3, NSDAN, diap3, mDia2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | diaphanous-related formin 3 |
| Other Description | diaphanous homolog 3|diaphanous-related formin-3|protein diaphanous homolog 3 |
| Swissprots | A2A3B9 Q2KPB6 Q5JTP8 Q6NUP0 A2A3B8 Q86VS4 Q5T2S7 Q18PA1 Q9NSV4 Q3ZK23 Q18P99 Q18PA0 Q5XKF6 Q8NAV4 A2A3C0 Q6MZF0 |
| Accessions | EAW52069 EAW52070 EAW52071 EAW52072 EAW52073 EAW52074 Q9NSV4 AB244756 BAE96350 AB244757 BAE96351 AB244758 BAE96352 AK092024 BAC03793 AK298509 BAG60715 AK307652 AK316474 BAH14845 AL137718 CAB70890 AY750055 AAW73254 AY818645 AAW78862 BC034952 AAH34952 BC041395 AAH41395 BC048963 AAH48963 BC068504 AAH68504 BF979672 BG203073 BX649186 CAE46204 CA310418 XM_006719876 XP_006719939 XM_011535258 XP_011533560 XM_011535259 XP_011533561 XM_011535260 XP_011533562 XM_011535261 XP_011533563 XM_011535262 XP_011533564 XM_011535263 XP_011533565 XM_011535264 XP_011533566 XM_011535265 XP_011533567 XR_941672 NM_001042517 NP_001035982 NM_001258366 NP_001245295 NM_001258367 NP_001245296 NM_001258368 NP_001245297 NM_001258369 NP_001245298 NM_001258370 NP_001245299 NM_030932 NP_112194 |
| Function | Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:18755006, ECO:0000269|PubMed:19457867}. Note=During mitosis, co-localizes with the actin-rich cleavage furrow and with the microtubule-rich central spindle during cytokinesis. |
| Top Pathways | Regulation of actin cytoskeleton |
DIAPH3 CRISPR/Cas9 KO Plasmid (h) - sc-416734 from Santa Cruz Biotechnology
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DIAPH3 HDR Plasmid (h) - sc-416734-HDR from Santa Cruz Biotechnology
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DIAPH3 Double Nickase Plasmid (h) - sc-416734-NIC from Santa Cruz Biotechnology
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DIAPH3 Double Nickase Plasmid (h2) - sc-416734-NIC-2 from Santa Cruz Biotechnology
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DIAPH3 CRISPR Activation Plasmid (h) - sc-416734-ACT from Santa Cruz Biotechnology
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DIAPH3 CRISPR Activation Plasmid (h2) - sc-416734-ACT-2 from Santa Cruz Biotechnology
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DIAPH3 Lentiviral Activation Particles (h) - sc-416734-LAC from Santa Cruz Biotechnology
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DIAPH3 Lentiviral Activation Particles (h2) - sc-416734-LAC-2 from Santa Cruz Biotechnology
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DIAPH3 siRNA (h) - sc-62210 from Santa Cruz Biotechnology
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DIAPH3 shRNA Plasmid (h) - sc-62210-SH from Santa Cruz Biotechnology
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DIAPH3 shRNA (h) Lentiviral Particles - sc-62210-V from Santa Cruz Biotechnology
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DIAPH3 RNAi - H00081624-R02 from Novus Biologicals
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MISSION® esiRNA - EHU090271 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7232 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7232 from Sigma-Aldrich
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DIAPH3 siRNA (Human) - CRJ3032 from Cohesion Biosciences
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DIAPH3 RNAi - H00081624-R01 from Novus Biologicals
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DIAPH3 - MBS8201402 from MyBioSource
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shRNA set against Human DIAPH3 (NM_030932.3) - SHH278045 from Creative biogene
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shRNA set against Human DIAPH3(NM_001042517.1) - SHH005321 from Creative biogene
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shRNA set against Human DIAPH3(NM_030932.3) - SHH005339 from Creative biogene
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Human DIAPH3 siRNA - orb273533 from Biorbyt
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DIAPH3 shRNA Plasmid (Human) - CHJ3032 from Cohesion Biosciences
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DIAPH3 miRNA 3'UTR clone - MiUTR1H-02823 from Creative biogene
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DIAPH3 miRNA 3'UTR clone - MiUTR1H-02824 from Creative biogene
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