MINA

Gene Symbol	MINA
Entrez Gene	84864
Alt Symbol	MDIG, MINA53, NO52, ROX
Species	Human
Gene Type	protein-coding
Description	MYC induced nuclear antigen
Other Description	60S ribosomal protein L27a histidine hydroxylase\|bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA\|histone lysine demethylase MINA\|mineral dust induced gene protein\|mineral dust-induced gene protein\|myc-induced nuclear antigen, 53 kDa\|nucleolar protein 52\|ribosomal oxygenase MINA
Swissprots	Q8IUF6 Q8IU69 D3DN35 Q6SKS0 Q6AHW4 Q96C17 Q8IUF7 Q96KB0 Q8IUF8
Accessions	EAW79872 EAW79873 EAW79874 EAW79875 Q8IUF8 AB083189 BAC16537 AB083190 BAC16358 AB083191 BAC16359 AB083192 BAC16360 AB083193 BAC16361 AK027299 BAB55024 AL550737 AY302110 AAP59421 AY390536 AAR27293 AY456380 AAR21572 BC014928 AAH14928 BM979079 CR627479 CAH10679 DA310030 DA696177 DQ453796 ABE28016 XM_005247838 XP_005247895 XM_011513244 XP_011511546 XR_241516 NM_001042533 NP_001035998 NM_001261829 NP_001248758 NM_032778 NP_116167 NM_153182 NP_694822
Function	Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. {ECO:0000269\|PubMed:12091391, ECO:0000269\|PubMed:14695334, ECO:0000269\|PubMed:15534111, ECO:0000269\|PubMed:15819408, ECO:0000269\|PubMed:15897898, ECO:0000269\|PubMed:17317935, ECO:0000269\|PubMed:19502796, ECO:0000269\|PubMed:23103944}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:12091391, ECO:0000269\|PubMed:15819408}. Nucleus, nucleolus {ECO:0000269\|PubMed:12091391, ECO:0000269\|PubMed:15819408}.
Tissue Specificity	Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines. {ECO:0000269\|PubMed:14695334, ECO:0000269\|PubMed:15534111, ECO:0000269\|PubMed:15897898, ECO:0000269\|PubMed:19502796}.

Mina53 (H-4) - sc-398521 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

Mina53 (H-4): sc-398521. Western blot analysis of Mina53 expression in Jurkat whole cell lysate.

Mina53 (C-15) - sc-74971 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Mina53 (L-16) - sc-74973 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-MINA53 antibody - ab126282 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunofluorescence of MINA53 in mouse heart tissue with ab126282 at 20 ug/mL.

Anti-MINA53 antibody - ab50908 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MINA53 antibody (ab50908) at 1.25 µg/ml + HepG2 cell Lysate (10µg)SecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-MINA53 antibody - ab191494 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-MINA53 antibody (ab191494)Lane 1 : HEK293T whole cell lysateLane 2 : NIH-3T3 whole cell lysateLane 3 : PC12 whole cell lysate

Anti-MINA53 antibody - ab155335 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin embedded HBL435 xenograft, labeling MINA53 with ab155335 at 1/500.

Anti-MINA53 antibody - ab169154 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-MINA53 antibody (ab169154) at 1 µg/ml + Human placenta lysate at 50 µgdeveloped using the ECL technique

Anti-MINA / MINA53 Antibody (C-Terminus, AP) - LS-C225908 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MINA / MINA53 Antibody (C-Terminus, APC) - LS-C225910 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MINA / MINA53 Antibody (C-Terminus, Biotin) - LS-C225911 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MINA / MINA53 Antibody (C-Terminus, FITC) - LS-C225912 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MINA / MINA53 Antibody (C-Terminus) - LS-C31648 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MINA / MINA53 Antibody (C-Terminus, PE) - LS-C225915 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MINA / MINA53 Antibody (C-Terminus, Azide-free, HRP) - LS-C225914 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MINA / MINA53 Antibody (C-Terminus, Azide-free) - LS-C327911 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MINA / MINA53 Antibody (N-Terminus) - LS-C31546 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

MINA antibody LS-C31546 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-MINA / MINA53 Antibody - LS-C332072 from LifeSpan Bioscience

Prices	$305.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MINA / MINA53 Antibody (aa107-156) - LS-C109550 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

MINA antibody LS-C109550 Western blot of Fetal Liver lysate.

Anti-MINA / MINA53 Antibody - LS-C341065 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MINA / MINA53 Antibody (aa374-423) - LS-C201203 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Western blot of Human Breast Tumor. MINA antibody dilution 1.0 ug/ml.

Anti-MINA / MINA53 Antibody (N-Terminus) - LS-C30285 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

MINA antibody LS-C30285 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-MINA / MINA53 Antibody - LS-C334852 from LifeSpan Bioscience

Prices	$255.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of various cell lines, using MINA antibody.

Anti-MINA / MINA53 Antibody (aa1-30) - LS-C164198 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Western blot of MINA (arrow) using rabbit polyclonal MINA Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the MINA gene.

Anti-MINA / MINA53 Antibody (aa397-429) - LS-C96544 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with MINA , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

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