| Gene Symbol |
MINA
|
| Entrez Gene |
84864
|
| Alt Symbol |
MDIG, MINA53, NO52, ROX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MYC induced nuclear antigen
|
| Other Description |
60S ribosomal protein L27a histidine hydroxylase|bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA|histone lysine demethylase MINA|mineral dust induced gene protein|mineral dust-induced gene protein|myc-induced nuclear antigen, 53 kDa|nucleolar protein 52|ribosomal oxygenase MINA
|
| Swissprots |
Q8IUF6 Q8IU69 D3DN35 Q6SKS0 Q6AHW4 Q96C17 Q8IUF7 Q96KB0 Q8IUF8
|
| Accessions |
EAW79872 EAW79873 EAW79874 EAW79875 Q8IUF8 AB083189 BAC16537 AB083190 BAC16358 AB083191 BAC16359 AB083192 BAC16360 AB083193 BAC16361 AK027299 BAB55024 AL550737 AY302110 AAP59421 AY390536 AAR27293 AY456380 AAR21572 BC014928 AAH14928 BM979079 CR627479 CAH10679 DA310030 DA696177 DQ453796 ABE28016 XM_005247838 XP_005247895 XM_011513244 XP_011511546 XR_241516 NM_001042533 NP_001035998 NM_001261829 NP_001248758 NM_032778 NP_116167 NM_153182 NP_694822
|
| Function |
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:14695334, ECO:0000269|PubMed:15534111, ECO:0000269|PubMed:15819408, ECO:0000269|PubMed:15897898, ECO:0000269|PubMed:17317935, ECO:0000269|PubMed:19502796, ECO:0000269|PubMed:23103944}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:15819408}. Nucleus, nucleolus {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:15819408}.
|
| Tissue Specificity |
Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines. {ECO:0000269|PubMed:14695334, ECO:0000269|PubMed:15534111, ECO:0000269|PubMed:15897898, ECO:0000269|PubMed:19502796}.
|
