| Gene Symbol |
SENP8
|
| Entrez Gene |
123228
|
| Alt Symbol |
DEN1, NEDP1, PRSC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SUMO/sentrin specific peptidase family member 8
|
| Other Description |
NEDD8 specific-protease cysteine 2|NEDD8-specific protease 1|SUMO sentrin specific protease family member 8|deneddylase 1|deneddylase-1|protease, cysteine 2|sentrin-specific protease 8
|
| Swissprots |
Q96LD8 Q96QA4
|
| Accessions |
CAK32309 EAW77881 Q96LD8 AF308450 AAL06294 AK097557 AK292298 BAF84987 AY008293 AAG21828 BC031411 AAH31411 BP370384 CN367895 DB033241 DB048641 DQ890802 ABM81728 DQ893957 ABM84883 XM_005254157 XP_005254214 XM_011521215 XP_011519517 XM_011521216 XP_011519518 XM_011521217 XP_011519519 NM_001166340 NP_001159812 NM_001172109 NP_001165580 NM_001172110 NP_001165581 NM_001172111 NP_001165582 NM_145204 NP_660205
|
| Function |
Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. {ECO:0000269|PubMed:12730221, ECO:0000269|PubMed:12759362, ECO:0000269|PubMed:12759363, ECO:0000269|PubMed:15242646, ECO:0000269|PubMed:15775960}.
|
| Tissue Specificity |
Broadly expressed, with highest levels in kidney and pancreas. {ECO:0000269|PubMed:12730221}.
|