OPHN1

Gene Symbol OPHN1
Entrez Gene 4983
Alt Symbol ARHGAP41, MRX60, OPN1
Species Human
Gene Type protein-coding
Description oligophrenin 1
Other Description mental retardation, X-linked 60|oligophrenin-1|oligophrenin-1, Rho-GTPase activating protein
Swissprots B9EIP8 Q6PCC1 Q8WX47 O60890 Q5JQ81
Accessions BAC80690 BAC80691 BAC80692 BAC80693 BAC80694 BAC80695 BAC80696 BAC80697 BAC80698 BAC80699 BAC80700 BAC80701 BAC80702 BAC80703 BAC80704 BAC80705 BAC80706 BAC80707 BAC80708 BAC80709 CAB96181 CAC07882 EAX05378 O60890 AB102656 BAC81125 AJ001189 CAA04579 AK295769 BAG58594 AK309665 AK309696 BC059393 AAH59393 BC140763 AAI40764 BP357826 XM_005262270 XP_005262327 XM_006724653 XP_006724716 XM_011530961 XP_011529263 NM_002547 NP_002538
Function Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). {ECO:0000250}.
Subcellular Location Cell junction, synapse. Cell projection, axon. Cell projection, dendritic spine. Cell projection, dendrite {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Present in both presynaptic and postsynaptic sites. {ECO:0000250}.
Tissue Specificity Expressed in brain.

Oligophrenin-1 Antibody - 11939 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various tissues and cell lines using Oligophrenin-1 Antibody.

oligophrenin-1 (E-4) - sc-376319 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
oligophrenin-1 (E-4): sc-376319. Western blot analysis of oligophrenin-1 expression in non-transfected: sc-117752 (A) and mouse oligophrenin-1 transfected: sc-110337 (B) 293T whole cell lysates.

oligophrenin-1 (A-12) - sc-374330 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
oligophrenin-1 (A-12): sc-374330. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

oligophrenin-1 (H-100) - sc-25631 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
oligophrenin-1 (H-100): sc-25631. Western blot analysis of oligophrenin-1 expression in rat brain tissue extract.

oligophrenin-1 (C-19) - sc-8374 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
oligophrenin-1 (C-19): sc-8374. Western blot analysis of oligophrenin-1 expression in H4 (A) and IMR-32 (B) whole cell lysates and mouse embryo (C), rat brain (D) and mouse brain (E) extracts.

Anti-OPHN1 antibody - ab57990 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57990 OPHN1 antibody at 1ug/ml.

Anti-OPHN1 Antibody (clone 2B9) - LS-C197823 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B9
Detection limit for recombinant GST tagged OPHN1 is approximately 0.3 ng/ml as a capture antibody.

OPHN1 Antibody - NBP1-88828 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: OPHN1 Antibody [NBP1-88828] - Staining of human cerebral cortex shows moderate cytoplasmic positivity in neuronal cells.

OPHN1 Antibody (2B9) - H00004983-M03 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B9

OPHN1 Antibody - H00004983-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Rabbit Anti-Oligophrenin 1 Polyclonal Antibody - bs-11469R from Bioss

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Anti-Oligophrenin 1 Polyclonal Antibody, Unconjugated(bs-11469R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-OPHN1 antibody produced in rabbit - HPA002919 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-OPHN1: <B>Cat. No. HPA002919</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of cells in exocrine pancreas.

Monoclonal Anti-OPHN1 antibody produced in mouse - WH0004983M3 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B9
<B>Immunoblotting</B><BR/>Monoclonal Anti-OPHN1, <B>Cat. No. WH0004983M3</B> used at the antibody concentration: 1 μg/mL. Specific band of ~36.45 kDa using immunogen protein lysate.

OPHN1-Antibody-monoclonal-M03 - AT3150a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B9
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.08 KDa) .
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