OPHN1

Gene Symbol OPHN1
Entrez Gene 4983
Alt Symbol ARHGAP41, MRX60, OPN1
Species Human
Gene Type protein-coding
Description oligophrenin 1
Other Description mental retardation, X-linked 60|oligophrenin-1|oligophrenin-1, Rho-GTPase activating protein
Swissprots B9EIP8 Q6PCC1 Q8WX47 O60890 Q5JQ81
Accessions BAC80690 BAC80691 BAC80692 BAC80693 BAC80694 BAC80695 BAC80696 BAC80697 BAC80698 BAC80699 BAC80700 BAC80701 BAC80702 BAC80703 BAC80704 BAC80705 BAC80706 BAC80707 BAC80708 BAC80709 CAB96181 CAC07882 EAX05378 O60890 AB102656 BAC81125 AJ001189 CAA04579 AK295769 BAG58594 AK309665 AK309696 BC059393 AAH59393 BC140763 AAI40764 BP357826 XM_005262270 XP_005262327 XM_006724653 XP_006724716 XM_011530961 XP_011529263 NM_002547 NP_002538
Function Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). {ECO:0000250}.
Subcellular Location Cell junction, synapse. Cell projection, axon. Cell projection, dendritic spine. Cell projection, dendrite {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Present in both presynaptic and postsynaptic sites. {ECO:0000250}.
Tissue Specificity Expressed in brain.

oligophrenin-1 CRISPR/Cas9 KO Plasmid (h) - sc-403694 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

oligophrenin-1 HDR Plasmid (h) - sc-403694-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

oligophrenin-1 Double Nickase Plasmid (h) - sc-403694-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

oligophrenin-1 Double Nickase Plasmid (h2) - sc-403694-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

oligophrenin-1 CRISPR Activation Plasmid (h) - sc-403694-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

oligophrenin-1 CRISPR Activation Plasmid (h2) - sc-403694-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

oligophrenin-1 Lentiviral Activation Particles (h) - sc-403694-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

oligophrenin-1 Lentiviral Activation Particles (h2) - sc-403694-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

oligophrenin-1 siRNA (h) - sc-36125 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

oligophrenin-1 shRNA Plasmid (h) - sc-36125-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

oligophrenin-1 shRNA (h) Lentiviral Particles - sc-36125-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU150751 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15738 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15738 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

OPHN1 siRNA (Human) - CRH3305 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

OPHN1 RNAi - H00004983-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human Ophn1 (NM_002547.2) - SHH366616 from Creative biogene

Category siRNA
Species Reactivities Human

OPHN1 shRNA Plasmid (Human) - CHH3305 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

OPHN1 miRNA 3'UTR clone - MiUTR4H-TG06251 from Creative biogene

Species Reactivities Human
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