| Gene Symbol | MARCH8 |
|---|---|
| Entrez Gene | 220972 |
| Alt Symbol | CMIR, MARCH-VIII, MIR, RNF178, c-MIR |
| Species | Human |
| Gene Type | protein-coding |
| Description | membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase |
| Other Description | E3 ubiquitin-protein ligase MARCH8|RING finger protein 178|c-mir, cellular modulator of immune recognition|cellular modulator of immune recognition (c-MIR)|membrane-associated RING finger protein 8|membrane-associated RING-CH protein VIII |
| Swissprots | H0Y7C6 Q5T0T0 Q8TC72 Q5T0S8 B2R8E7 |
| Accessions | EAW86644 EAW86645 EAW86646 EAW86647 EAW86648 EAW86649 EAW86650 EAW86651 EAW86652 Q5T0T0 AA418494 AK023636 AK025472 AK057289 AK125414 AK307667 AK313340 BAG36144 AL833316 BC025394 AAH25394 BC066988 AAH66988 BF195460 BG433948 BG717635 BM151615 BM906478 DQ588226 DQ595937 DQ599376 HY047787 XM_005271804 XP_005271861 XM_006717704 XP_006717767 XM_006717705 XP_006717768 XM_011539492 XP_011537794 XM_011539493 XP_011537795 XM_011539494 XP_011537796 XM_011539495 XP_011537797 XR_246519 NM_001002265 NM_001002266 NP_001002266 NM_001282866 NP_001269795 NM_145021 NP_659458 |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS. {ECO:0000269|PubMed:12582153, ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:18389477, ECO:0000269|PubMed:19117940, ECO:0000269|PubMed:19566897}. |
| Subcellular Location | Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. |
| Tissue Specificity | Broadly expressed. Present in immature dendritic cells (at protein level). {ECO:0000269|PubMed:12582153, ECO:0000269|PubMed:14722266}. |
Human-MARCH8-cDNA-Clone - DC05480 from Abgent, a WuXi AppTec company
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Human MARCH8 cDNA clone(NM_145021.4) - CDFG008826 from Creative Biomart
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Human MARCH8 cDNA clone(NM_001002265.1) - CDFH011083 from Creative Biomart
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Human MARCH8 cDNA clone(NM_001002266.1) - CDFH011084 from Creative Biomart
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Human MARCH8 ORF Clone(NM_001002265.1) - CDCL169634 from Creative Biomart
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Human MARCH8 ORF Clone(NM_145021.4) - CDCR318040 from Creative Biomart
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Human MARCH8 ORF Clone(NM_145021.4) - CDCR318041 from Creative Biomart
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Human MARCH8 ORF Clone(NM_145021.4) - CDCR318042 from Creative Biomart
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Human MARCH8 ORF Clone(NM_001002265.1) - CDCR338713 from Creative Biomart
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Human MARCH8 ORF Clone(NM_001002265.1) - CDCR338714 from Creative Biomart
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Human MARCH8 ORF Clone(NM_001002265.1) - CDCR338715 from Creative Biomart
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Human MARCH8 ORF Clone(NM_001002266.1) - CDCR338716 from Creative Biomart
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Human MARCH8 ORF Clone(NM_001002266.1) - CDCR338717 from Creative Biomart
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Human MARCH8 ORF Clone(NM_001002266.1) - CDCR338718 from Creative Biomart
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Human MARCH8 ORF Clone(NM_145021.4) - CDCR318040 from Creative biogene
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Human MARCH8 ORF Clone(NM_001002266.1) - CDCR338716 from Creative biogene
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Human MARCH8 ORF clone (NM_001002265.1) - CDCL130689 from Creative biogene
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Human MARCH8 ORF Clone (BC025394) - CDCS416969 from Creative biogene
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Human MARCH8 cDNA Clone(NM_145021.4) - CDFG008826 from Creative biogene
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Human MARCH8 cDNA Clone(NM_001002265.1) - CDFH011083 from Creative biogene
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Human MARCH8 cDNA Clone(NM_001002266.1) - CDFH011084 from Creative biogene
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