MARCH8

Gene Symbol	MARCH8
Entrez Gene	220972
Alt Symbol	CMIR, MARCH-VIII, MIR, RNF178, c-MIR
Species	Human
Gene Type	protein-coding
Description	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase MARCH8|RING finger protein 178|c-mir, cellular modulator of immune recognition|cellular modulator of immune recognition (c-MIR)|membrane-associated RING finger protein 8|membrane-associated RING-CH protein VIII
Swissprots	H0Y7C6 Q5T0T0 Q8TC72 Q5T0S8 B2R8E7
Accessions	EAW86644 EAW86645 EAW86646 EAW86647 EAW86648 EAW86649 EAW86650 EAW86651 EAW86652 Q5T0T0 AA418494 AK023636 AK025472 AK057289 AK125414 AK307667 AK313340 BAG36144 AL833316 BC025394 AAH25394 BC066988 AAH66988 BF195460 BG433948 BG717635 BM151615 BM906478 DQ588226 DQ595937 DQ599376 HY047787 XM_005271804 XP_005271861 XM_006717704 XP_006717767 XM_006717705 XP_006717768 XM_011539492 XP_011537794 XM_011539493 XP_011537795 XM_011539494 XP_011537796 XM_011539495 XP_011537797 XR_246519 NM_001002265 NM_001002266 NP_001002266 NM_001282866 NP_001269795 NM_145021 NP_659458
Function	E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS. {ECO:0000269|PubMed:12582153, ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:18389477, ECO:0000269|PubMed:19117940, ECO:0000269|PubMed:19566897}.
Subcellular Location	Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Tissue Specificity	Broadly expressed. Present in immature dendritic cells (at protein level). {ECO:0000269|PubMed:12582153, ECO:0000269|PubMed:14722266}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MARCH8 full length protein - ab165955 from Abcam Category Protein Source Wheat germ Species Human

Human MARCH8 full length protein - ab88197 from Abcam Category Protein Source Saccharomyces cerevisiae Species Human

Human MARCH8 protein fragment - ab165956 from Abcam Category Protein Source Wheat germ Species Human

MARCH8 Antibody Blocking Peptide - LS-E15967 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MARCH8 Antibody Blocking Peptide - LS-E15808 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MARCH8 Antibody Blocking Peptide - LS-E15809 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MARCH8 Antibody Blocking Peptide - LS-E30604 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MARCH8 Partial Recombinant Protein - H00220972-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human MARCH8 Protein - H00220972-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MARCH8 Peptide - GTX85022-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

RNF178 Blocking Peptide - 33R-6473 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF178 Blocking Peptide - 33R-10283 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF178 Blocking Peptide - 33R-1760 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MARCH8 - H00220972-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MARCH8 - H00220972-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MARCH8 - H00220972-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MARCH8 - H00220972-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MARCH8 Control Peptide - AP30538CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

MARCH8 Peptide - 4885P from ProSci Category Peptide Species Human

MARCH8 fusion protein - Ag5268 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

MARCH8 fusion protein - ag5379 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human MARCH8 - MARCH8-26832TH from Creative Biomart Category Protein

Recombinant Human 41341, GST-tagged - MARCH8-748H from Creative Biomart Category Protein Source E.coli Species Human

MARCH8 (transcript variant 7) - TP305477 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MARCH8 (transcript variant 8) - TP309891 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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