MARCH8

Gene Symbol MARCH8
Entrez Gene 220972
Alt Symbol CMIR, MARCH-VIII, MIR, RNF178, c-MIR
Species Human
Gene Type protein-coding
Description membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase MARCH8|RING finger protein 178|c-mir, cellular modulator of immune recognition|cellular modulator of immune recognition (c-MIR)|membrane-associated RING finger protein 8|membrane-associated RING-CH protein VIII
Swissprots H0Y7C6 Q5T0T0 Q8TC72 Q5T0S8 B2R8E7
Accessions EAW86644 EAW86645 EAW86646 EAW86647 EAW86648 EAW86649 EAW86650 EAW86651 EAW86652 Q5T0T0 AA418494 AK023636 AK025472 AK057289 AK125414 AK307667 AK313340 BAG36144 AL833316 BC025394 AAH25394 BC066988 AAH66988 BF195460 BG433948 BG717635 BM151615 BM906478 DQ588226 DQ595937 DQ599376 HY047787 XM_005271804 XP_005271861 XM_006717704 XP_006717767 XM_006717705 XP_006717768 XM_011539492 XP_011537794 XM_011539493 XP_011537795 XM_011539494 XP_011537796 XM_011539495 XP_011537797 XR_246519 NM_001002265 NM_001002266 NP_001002266 NM_001282866 NP_001269795 NM_145021 NP_659458
Function E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS. {ECO:0000269|PubMed:12582153, ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:18389477, ECO:0000269|PubMed:19117940, ECO:0000269|PubMed:19566897}.
Subcellular Location Cytoplasmic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
Tissue Specificity Broadly expressed. Present in immature dendritic cells (at protein level). {ECO:0000269|PubMed:12582153, ECO:0000269|PubMed:14722266}.

MARCH8 CRISPR/Cas9 KO Plasmid (h) - sc-405928 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MARCH8 HDR Plasmid (h) - sc-405928-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MARCH8 Double Nickase Plasmid (h) - sc-405928-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MARCH8 Double Nickase Plasmid (h2) - sc-405928-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MARCH8 CRISPR Activation Plasmid (h) - sc-405928-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MARCH8 CRISPR Activation Plasmid (h2) - sc-405928-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MARCH8 Lentiviral Activation Particles (h) - sc-405928-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MARCH8 Lentiviral Activation Particles (h2) - sc-405928-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MARCH8 siRNA (h) - sc-90432 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MARCH8 shRNA Plasmid (h) - sc-90432-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MARCH8 shRNA (h) Lentiviral Particles - sc-90432-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MARCH8 RNAi - H00220972-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MARCH8 RNAi - H00220972-R03 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU007521 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13037 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13037 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06623 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06623

MARCH8 siRNA (Human) - CRJ6476 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MARCH8 RNAi - H00220972-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human MARCH8 (NM_145021.4) - SHH338303 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MARCH8(NM_001002265.1) - SHH177185 from Creative biogene

Category siRNA
Species Reactivities Human

Human MARCH8 siRNA - orb276977 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MARCH8 shRNA Plasmid (Human) - CHJ6476 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MARCH8 miRNA 3'UTR clone - MiUTR1H-06110 from Creative biogene

Species Reactivities Human

MARCH8 miRNA 3'UTR clone - MiUTR3H-12849 from Creative biogene

Species Reactivities Human
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