| Gene Symbol |
N6AMT1
|
| Entrez Gene |
29104
|
| Alt Symbol |
C21orf127, HEMK2, MTQ2, N6AMT, PRED28, m.HsaHemK2P
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N-6 adenine-specific DNA methyltransferase 1 (putative)
|
| Other Description |
N6-DNA-methyltransferase|hemK methyltransferase family member 2|n(6)-adenine-specific DNA methyltransferase 1
|
| Swissprots |
Q96F73 Q9Y5N5
|
| Accessions |
CAB90428 EAX09939 EAX09940 EAX09941 Q9Y5N5 AA825430 AF139682 AAD38520 AK021678 AK092128 AK225515 AK314100 BAG36794 AW136986 BC011554 AAH11554 BP317563 BQ021620 BU631971 NM_013240 NP_037372 NM_182749 NP_877426 NR_047510
|
| Function |
Heterodimeric methyltransferase that catalyzes N5- methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. {ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:21193388}.
|
| Tissue Specificity |
Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland. {ECO:0000269|PubMed:21193388}.
|