Gene Symbol | N6AMT1 |
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Entrez Gene | 29104 |
Alt Symbol | C21orf127, HEMK2, MTQ2, N6AMT, PRED28, m.HsaHemK2P |
Species | Human |
Gene Type | protein-coding |
Description | N-6 adenine-specific DNA methyltransferase 1 (putative) |
Other Description | N6-DNA-methyltransferase|hemK methyltransferase family member 2|n(6)-adenine-specific DNA methyltransferase 1 |
Swissprots | Q96F73 Q9Y5N5 |
Accessions | CAB90428 EAX09939 EAX09940 EAX09941 Q9Y5N5 AA825430 AF139682 AAD38520 AK021678 AK092128 AK225515 AK314100 BAG36794 AW136986 BC011554 AAH11554 BP317563 BQ021620 BU631971 NM_013240 NP_037372 NM_182749 NP_877426 NR_047510 |
Function | Heterodimeric methyltransferase that catalyzes N5- methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. {ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:21193388}. |
Tissue Specificity | Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland. {ECO:0000269|PubMed:21193388}. |
Human HEMK2 full length protein - ab162221 from Abcam
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Human HEMK2 full length protein - ab187466 from Abcam
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Human HEMK2 protein fragment - ab162222 from Abcam
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N6AMT1 Antibody Blocking Peptide - LS-E5579 from LifeSpan Bioscience
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N6AMT1 Antibody Blocking Peptide - LS-E16724 from LifeSpan Bioscience
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HEMK2 Recombinant Protein - H00029104-P01 from Novus Biologicals
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HEMK2 Partial Recombinant Protein - H00029104-Q01 from Novus Biologicals
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N6AMT1-Antibody-N-term-Blocking-Peptide - BP18103a from Abgent, a WuXi AppTec company
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Human N6AMT1 His tag protein - orb84749 from Biorbyt
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N6AMT1 Blocking Peptide - 33R-5659 from Fitzgerald
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N6AMT1 protein (His tag) - 80R-4006 from Fitzgerald
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N6AMT1 / HEMK2 (1-214, His-tag) - AR51691PU-N from Acris Antibodies
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N6AMT1 / HEMK2 (1-214, His-tag) - AR51691PU-S from Acris Antibodies
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N6AMT1 / HEMK2 - H00029104-P01-10 from Acris Antibodies
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N6AMT1 / HEMK2 - H00029104-P01-25 from Acris Antibodies
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N6AMT1 / HEMK2 - H00029104-Q01-10 from Acris Antibodies
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N6AMT1 / HEMK2 - H00029104-Q01-25 from Acris Antibodies
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N6AMT1 fusion protein - ag9204 from Proteintech Group
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N6AMT1 fusion protein - Ag9310 from Proteintech Group
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Recombinant Human N6AMT1, His tagged - N6AMT1-2530H from Creative Biomart
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Recombinant Human N-6 adenine-specific DNA methyltransferase 1 (putative), His-tagged - N6AMT1-648H from Creative Biomart
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Human N6AMT1 / HEMK2 Protein (His Tag) - 12399-H08E-50 from Sino Biological
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Recombinant Human HemK methyltransferase family member 2(N6AMT1) - CSB-YP010286HU CSB-EP010286HU CSB-BP010286HU CSB-MP010286HU from Cusabio
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N6AMT1, 1-214aa, Human, His tag, E.coli - ATGP2871 from ATGen
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N6AMT1 / HEMK2 (full length, N-term HIS tag, transcript variant 2) - TP760107 from Acris Antibodies
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