Gene Symbol | N6AMT1 |
---|---|
Entrez Gene | 29104 |
Alt Symbol | C21orf127, HEMK2, MTQ2, N6AMT, PRED28, m.HsaHemK2P |
Species | Human |
Gene Type | protein-coding |
Description | N-6 adenine-specific DNA methyltransferase 1 (putative) |
Other Description | N6-DNA-methyltransferase|hemK methyltransferase family member 2|n(6)-adenine-specific DNA methyltransferase 1 |
Swissprots | Q96F73 Q9Y5N5 |
Accessions | CAB90428 EAX09939 EAX09940 EAX09941 Q9Y5N5 AA825430 AF139682 AAD38520 AK021678 AK092128 AK225515 AK314100 BAG36794 AW136986 BC011554 AAH11554 BP317563 BQ021620 BU631971 NM_013240 NP_037372 NM_182749 NP_877426 NR_047510 |
Function | Heterodimeric methyltransferase that catalyzes N5- methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. {ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:21193388}. |
Tissue Specificity | Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland. {ECO:0000269|PubMed:21193388}. |
HEMK2 CRISPR/Cas9 KO Plasmid (h) - sc-406503 from Santa Cruz Biotechnology
|
||||||||
HEMK2 HDR Plasmid (h) - sc-406503-HDR from Santa Cruz Biotechnology
|
||||||||
HEMK2 Double Nickase Plasmid (h) - sc-406503-NIC from Santa Cruz Biotechnology
|
||||||||
HEMK2 Double Nickase Plasmid (h2) - sc-406503-NIC-2 from Santa Cruz Biotechnology
|
||||||||
HEMK2 CRISPR Activation Plasmid (h) - sc-406503-ACT from Santa Cruz Biotechnology
|
||||||||
HEMK2 CRISPR Activation Plasmid (h2) - sc-406503-ACT-2 from Santa Cruz Biotechnology
|
||||||||
HEMK2 Lentiviral Activation Particles (h) - sc-406503-LAC from Santa Cruz Biotechnology
|
||||||||
HEMK2 Lentiviral Activation Particles (h2) - sc-406503-LAC-2 from Santa Cruz Biotechnology
|
||||||||
HEMK2 siRNA (h) - sc-91423 from Santa Cruz Biotechnology
|
||||||||
HEMK2 shRNA Plasmid (h) - sc-91423-SH from Santa Cruz Biotechnology
|
||||||||
HEMK2 shRNA (h) Lentiviral Particles - sc-91423-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU113931 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN14901 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14901 from Sigma-Aldrich
|
||||||||
N6AMT1 siRNA (Human) - CRH9195 from Cohesion Biosciences
|
||||||||
HEMK2 RNAi - H00029104-R01 from Novus Biologicals
|
||||||||
HEMK2 RNAi - H00029104-R02 from Novus Biologicals
|
||||||||
HEMK2 CRISPR/Cas9 KO Plasmid (h2) - sc-406503-KO-2 from Santa Cruz Biotechnology
|
||||||||
HEMK2 HDR Plasmid (h2) - sc-406503-HDR-2 from Santa Cruz Biotechnology
|
||||||||
shRNA set against Human N6AMT1 (NM_182749.3) - SHH348712 from Creative biogene
|
||||||||
N6AMT1 shRNA Plasmid (Human) - CHH9195 from Cohesion Biosciences
|
||||||||
N6AMT1 miRNA 3'UTR clone - MiUTR4H-TG05809 from Creative biogene
|