Aldh3a1
| Gene Symbol | Aldh3a1 |
|---|---|
| Entrez Gene | 11670 |
| Alt Symbol | Ahd-4, Ahd4, Aldh, Aldh3 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | aldehyde dehydrogenase family 3, subfamily A1 |
| Other Description | alcohol dehydrogenase family 3, subfamily A1|aldehyde dehydrogenase 3, stomach cytosolic (class 3)|aldehyde dehydrogenase 4|aldehyde dehydrogenase family 3 member A1|aldehyde dehydrogenase, dimeric NADP-preferring|dioxin-inducible aldehyde dehydrogenase 3 |
| Swissprots | B1ATI7 Q9R203 P47739 |
| Accessions | AAC05795 P47739 AF072815 AAD15964 AK144241 BAE25792 BC144946 AAI44947 BC150677 AAI50678 EL957097 EL959139 EL959277 EL961165 EL963960 U12785 AAA20670 XM_006532023 XP_006532086 XM_006532024 XP_006532087 XM_006532025 XP_006532088 XM_006532026 XP_006532089 XM_006532027 XP_006532090 XM_006532028 XP_006532091 NM_001112725 NP_001106196 NM_007436 NP_031462 |
| Function | ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes and in preventing corneal damage caused by ultraviolet light. {ECO:0000269|PubMed:10376761, ECO:0000269|PubMed:11784860}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Constitutively expressed in cornea, stomach, skin, bladder and lungs. Lowest expression levels in lungs and bladder. {ECO:0000269|PubMed:10376761}. |
| Top Pathways | Chemical carcinogenesis, Glycolysis / Gluconeogenesis, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450, Tyrosine metabolism |
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