Gene Symbol | Aldh3a1 |
---|---|
Entrez Gene | 11670 |
Alt Symbol | Ahd-4, Ahd4, Aldh, Aldh3 |
Species | Mouse |
Gene Type | protein-coding |
Description | aldehyde dehydrogenase family 3, subfamily A1 |
Other Description | alcohol dehydrogenase family 3, subfamily A1|aldehyde dehydrogenase 3, stomach cytosolic (class 3)|aldehyde dehydrogenase 4|aldehyde dehydrogenase family 3 member A1|aldehyde dehydrogenase, dimeric NADP-preferring|dioxin-inducible aldehyde dehydrogenase 3 |
Swissprots | B1ATI7 Q9R203 P47739 |
Accessions | AAC05795 P47739 AF072815 AAD15964 AK144241 BAE25792 BC144946 AAI44947 BC150677 AAI50678 EL957097 EL959139 EL959277 EL961165 EL963960 U12785 AAA20670 XM_006532023 XP_006532086 XM_006532024 XP_006532087 XM_006532025 XP_006532088 XM_006532026 XP_006532089 XM_006532027 XP_006532090 XM_006532028 XP_006532091 NM_001112725 NP_001106196 NM_007436 NP_031462 |
Function | ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes and in preventing corneal damage caused by ultraviolet light. {ECO:0000269|PubMed:10376761, ECO:0000269|PubMed:11784860}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Constitutively expressed in cornea, stomach, skin, bladder and lungs. Lowest expression levels in lungs and bladder. {ECO:0000269|PubMed:10376761}. |
Top Pathways | Chemical carcinogenesis, Glycolysis / Gluconeogenesis, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450, Tyrosine metabolism |
ALDH3A1 CRISPR/Cas9 KO Plasmid (m) - sc-419080 from Santa Cruz Biotechnology
|
||||||||
ALDH3A1 HDR Plasmid (m) - sc-419080-HDR from Santa Cruz Biotechnology
|
||||||||
ALDH3A1 Double Nickase Plasmid (m) - sc-419080-NIC from Santa Cruz Biotechnology
|
||||||||
ALDH3A1 Double Nickase Plasmid (m2) - sc-419080-NIC-2 from Santa Cruz Biotechnology
|
||||||||
ALDH3A1 CRISPR Activation Plasmid (m) - sc-419080-ACT from Santa Cruz Biotechnology
|
||||||||
ALDH3A1 CRISPR Activation Plasmid (m2) - sc-419080-ACT-2 from Santa Cruz Biotechnology
|
||||||||
ALDH3A1 Lentiviral Activation Particles (m) - sc-419080-LAC from Santa Cruz Biotechnology
|
||||||||
ALDH3A1 Lentiviral Activation Particles (m2) - sc-419080-LAC-2 from Santa Cruz Biotechnology
|
||||||||
ALDH3A1 siRNA (m) - sc-72033 from Santa Cruz Biotechnology
|
||||||||
ALDH3A1 shRNA Plasmid (m) - sc-72033-SH from Santa Cruz Biotechnology
|
||||||||
ALDH3A1 shRNA (m) Lentiviral Particles - sc-72033-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EMU046471 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN26551 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26551 from Sigma-Aldrich
|
||||||||
ALDH3A1 siRNA (Mouse) - CRM0138 from Cohesion Biosciences
|
||||||||
ALDH3A1 - MBS8212575 from MyBioSource
|
||||||||
shRNA set against Mouse ALDH3A1 (NM_007436.2) - SHH234886 from Creative biogene
|
||||||||
shRNA set against Mouse Aldh3a1(NM_007436.2) - SHG052813 from Creative biogene
|
||||||||
ALDH3A1 CRISPR/Cas9 KO Plasmid (m2) - sc-419080-KO-2 from Santa Cruz Biotechnology
|
||||||||
ALDH3A1 HDR Plasmid (m2) - sc-419080-HDR-2 from Santa Cruz Biotechnology
|
||||||||
ALDH3A1 shRNA Plasmid (Mouse) - CHM0138 from Cohesion Biosciences
|
||||||||
ALDH3A1 miRNA 3'UTR clone - MiUTR1M-01396 from Creative biogene
|