ADAM22

Gene Symbol ADAM22
Entrez Gene 53616
Alt Symbol ADAM 22, MDC2
Species Human
Gene Type protein-coding
Description ADAM metallopeptidase domain 22
Other Description a disintegrin and metalloproteinase domain 22|disintegrin and metalloproteinase domain-containing protein 22|metalloproteinase-disintegrin ADAM22-3|metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
Swissprots Q9UKK2 Q9P0K2 O75076 O75075 Q9UIA1 Q9P0K1
Accessions AAD55253 AAP21878 AAS07417 EAW76913 EAW76914 EAW76915 EAW76916 EAW76917 EAW76918 EAW76919 EAW76920 EAW76921 EAW76922 EAW76923 EAW76924 EAW76925 EAW76926 EAW76927 EAW76928 EAW76929 Q9P0K1 AB009671 BAA32349 AF073291 AAF22476 AF155381 AAF73288 AF155382 AAF73289 AF158637 AAD55251 AK125432 BAG54196 AK291010 BAF83699 AL133090 BC036029 AAH36029 BC062433 AAH62433 BC092465 AAH92465 BC125117 BC125118 AAI25119 CA429662 DR000609 XM_005250445 XP_005250502 XM_006716028 XP_006716091 XM_006716029 XP_006716092 XM_011516318 XP_011514620 XM_011516319 XP_011514621 XM_011516320 XP_011514622 XM_011516321 XP_011514623 XM_011516322 XP_011514624 XM_011516323 XP_011514625 XM_011516324 XP_011514626 NM_004194 NP_004185 NM_016351 NP_057435 NM_021721 NP_068367 NM_021722 NP_068368 NM_021723 NP_068369
Function Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. {ECO:0000269|PubMed:12589811, ECO:0000269|PubMed:15882968, ECO:0000269|PubMed:16385342, ECO:0000269|PubMed:19692335}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q9R1V6}.
Tissue Specificity Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues. {ECO:0000269|PubMed:16385342}.

ADAM22 (C-2) - sc-373931 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ADAM22 (C-2): sc-373931. Western blot analysis of ADAM22 expression in non-transfected (A) and human ADAM22 transfected (B) whole cell lysates.

ADAM22 (H-60) - sc-366989 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ADAM22 (S-16) - sc-26001 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ADAM22 (S-16): sc-26001. Western blot analysis of ADAM22 expression in rat cerebellum tissue extract.

ADAM22 (T-19) - sc-25999 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ADAM22 (T-19): sc-25999. Western blot analysis of ADAM22 expression in rat cerebellum tissue extract.

Anti-ADAM22 antibody - ab56122 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ADAM22 antibody (ab56122) at 1/1000 dilutionLane 1 : Whole cell lysate from rat brain at 10 µlLane 2 : Whole cell lysate from rat brain at 5 µl

Anti-ADAM22 antibody - ab66497 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab66497 stained PC12 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab66497, 1/1000 dilution) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-ADAM22 antibody - ab56118 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ADAM22 antibody (ab56118) at 1/1000 dilutionLane 1 : Rat brain lysate at 10 µlLane 2 : Rat brain lysate at 5 µl

Anti-ADAM22 antibody - ab56133 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ADAM22 antibody (ab56133) at 1/1000 dilutionLane 1 : Cell media from human prostate cancer DU145 cells (treated with SF)Lane 2 : Cell media from human prostate cancer DU145 cells (treated with Retinoic acid))

Anti-ADAM22 antibody [S46-30] - ab167438 from Abcam

Host Mouse
Clonality Monoclonal
Clone S46-30

Anti-ADAM22 antibody [S46-30] - ab167443 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S46-30

Anti-ADAM22 antibody - Cytoplasmic domain - ab56161 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ADAM22 antibody - Cytoplasmic domain (ab56161) at 1/1000 dilutionLane 1 : Cell media from human prostate cancer DU145 cells (treated with SF) Lane 2 : Cell media from human prostate cancer DU145 cells (treated with Retinoic acid))

Anti-ADAM22 Antibody (aa444-526, clone S57-2, Atto 700) - LS-C228720 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S57-2

Anti-ADAM22 Antibody (aa444-526, clone S57-2, APC) - LS-C228721 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S57-2

Anti-ADAM22 Antibody (aa444-526, clone S57-2, Biotin) - LS-C228722 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S57-2

Anti-ADAM22 Antibody (aa444-526, clone S57-2, PE, Atto 594) - LS-C228725 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S57-2

Anti-ADAM22 Antibody (aa444-526, clone S57-2, FITC) - LS-C228723 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S57-2

Anti-ADAM22 Antibody (aa444-526, clone S57-2, PerCP) - LS-C228726 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S57-2

Anti-ADAM22 Antibody (aa444-526, clone S57-2, SA) - LS-C228728 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S57-2

Anti-ADAM22 Antibody (aa444-526, clone S57-2, RPE) - LS-C228727 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S57-2

Anti-ADAM22 Antibody (aa757-857, clone S46-30, Atto 655) - LS-C229998 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S46-30

Anti-ADAM22 Antibody (aa757-857, clone S46-30, Atto 633) - LS-C229997 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S46-30

Anti-ADAM22 Antibody (aa757-857, clone S46-30, Atto 700) - LS-C230000 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S46-30

Anti-ADAM22 Antibody (aa757-857, clone S46-30, Atto 680) - LS-C229999 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S46-30

Anti-ADAM22 Antibody (aa757-857, clone S46-30, AP) - LS-C230001 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S46-30

Anti-ADAM22 Antibody (aa757-857, clone S46-30, FITC) - LS-C230003 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S46-30
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