| Gene Symbol |
ADAM22
|
| Entrez Gene |
53616
|
| Alt Symbol |
ADAM 22, MDC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ADAM metallopeptidase domain 22
|
| Other Description |
a disintegrin and metalloproteinase domain 22|disintegrin and metalloproteinase domain-containing protein 22|metalloproteinase-disintegrin ADAM22-3|metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
|
| Swissprots |
Q9UKK2 Q9P0K2 O75076 O75075 Q9UIA1 Q9P0K1
|
| Accessions |
AAD55253 AAP21878 AAS07417 EAW76913 EAW76914 EAW76915 EAW76916 EAW76917 EAW76918 EAW76919 EAW76920 EAW76921 EAW76922 EAW76923 EAW76924 EAW76925 EAW76926 EAW76927 EAW76928 EAW76929 Q9P0K1 AB009671 BAA32349 AF073291 AAF22476 AF155381 AAF73288 AF155382 AAF73289 AF158637 AAD55251 AK125432 BAG54196 AK291010 BAF83699 AL133090 BC036029 AAH36029 BC062433 AAH62433 BC092465 AAH92465 BC125117 BC125118 AAI25119 CA429662 DR000609 XM_005250445 XP_005250502 XM_006716028 XP_006716091 XM_006716029 XP_006716092 XM_011516318 XP_011514620 XM_011516319 XP_011514621 XM_011516320 XP_011514622 XM_011516321 XP_011514623 XM_011516322 XP_011514624 XM_011516323 XP_011514625 XM_011516324 XP_011514626 NM_004194 NP_004185 NM_016351 NP_057435 NM_021721 NP_068367 NM_021722 NP_068368 NM_021723 NP_068369
|
| Function |
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. {ECO:0000269|PubMed:12589811, ECO:0000269|PubMed:15882968, ECO:0000269|PubMed:16385342, ECO:0000269|PubMed:19692335}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q9R1V6}.
|
| Tissue Specificity |
Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues. {ECO:0000269|PubMed:16385342}.
|