DERL2
| Gene Symbol | DERL2 |
|---|---|
| Entrez Gene | 51009 |
| Alt Symbol | CGI-101, DERtrin-2, F-LAN-1, F-LANa, FLANa |
| Species | Human |
| Gene Type | protein-coding |
| Description | derlin 2 |
| Other Description | Der1-like domain family, member 2|carcinoma related|degradation in endoplasmic reticulum protein 2|derlin-2 |
| Swissprots | Q9GZP9 Q9Y3A7 |
| Accessions | EAW90329 Q9GZP9 AF132289 AAG43049 AF151859 AAD34096 AF208065 AAL14869 AF242523 AAF99603 AK024574 AK092218 BC010890 AAH10890 BG110482 BM675359 BU199049 CA425310 CN362881 CN362882 CR457202 CAG33483 HQ448209 ADQ32689 HY051246 XM_006721539 XP_006721602 XM_011523914 XP_011522216 XM_011523915 XP_011522217 XR_934033 XR_934034 NM_001304777 NP_001291706 NM_001304779 NP_001291708 NM_016041 NP_057125 NR_130905 NR_130906 |
| Function | Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation. {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}; Multi- pass membrane protein {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}. |
| Tissue Specificity | Ubiquitous. Overexpressed in various hepatocarcinomas. {ECO:0000269|PubMed:11500051, ECO:0000269|PubMed:16449189}. |
| Top Pathways | Protein processing in endoplasmic reticulum |
Derlin-2 (D-10) - sc-398573 from Santa Cruz Biotechnology
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Derlin-2 (C-18) - sc-50824 from Santa Cruz Biotechnology
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Derlin-2 (T-16) - sc-50826 from Santa Cruz Biotechnology
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Derlin-2/3 (A-6) - sc-390289 from Santa Cruz Biotechnology
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Derlin-2/3 (FL-239) - sc-134847 from Santa Cruz Biotechnology
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Anti-DERL2 antibody - ab185087 from Abcam
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Anti-DERL2 antibody - ab71552 from Abcam
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Anti-DERL2 antibody - ab54550 from Abcam
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Anti-DERL2 antibody - C-terminal - ab135318 from Abcam
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Anti-DERL2 / Derlin-2 Antibody (N-Terminus) - LS-C47053 from LifeSpan Bioscience
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Anti-DERL2 / Derlin-2 Antibody (C-Terminus) - LS-C144813 from LifeSpan Bioscience
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Anti-DERL2 / Derlin-2 Antibody - LS-C154768 from LifeSpan Bioscience
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Anti-DERL2 / Derlin-2 Antibody (aa191-219, FITC) - LS-C213551 from LifeSpan Bioscience
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Anti-DERL2 / Derlin-2 Antibody (aa191-219, AP) - LS-C213549 from LifeSpan Bioscience
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Anti-DERL2 / Derlin-2 Antibody (C-Terminus) - LS-C152094 from LifeSpan Bioscience
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Anti-DERL2 / Derlin-2 Antibody (aa191-219, Biotin) - LS-C213552 from LifeSpan Bioscience
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Anti-DERL2 / Derlin-2 Antibody (aa191-219, APC) - LS-C213550 from LifeSpan Bioscience
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Anti-DERL2 / Derlin-2 Antibody (aa191-219, Azide-free, HRP) - LS-C213553 from LifeSpan Bioscience
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Anti-DERL2 / Derlin-2 Antibody (aa191-219, PE) - LS-C213554 from LifeSpan Bioscience
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Anti-DERL2 / Derlin-2 Antibody (C-Terminus, AP) - LS-C218917 from LifeSpan Bioscience
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Anti-DERL2 / Derlin-2 Antibody (aa191-219) - LS-C158194 from LifeSpan Bioscience
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Anti-DERL2 / Derlin-2 Antibody (C-Terminus, APC) - LS-C218920 from LifeSpan Bioscience
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Anti-DERL2 / Derlin-2 Antibody (C-Terminus, Biotin) - LS-C218921 from LifeSpan Bioscience
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Anti-DERL2 / Derlin-2 Antibody (C-Terminus, FITC) - LS-C218922 from LifeSpan Bioscience
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Anti-DERL2 / Derlin-2 Antibody (C-Terminus, Azide-free, HRP) - LS-C218923 from LifeSpan Bioscience
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