DERL2

Gene Symbol DERL2
Entrez Gene 51009
Alt Symbol CGI-101, DERtrin-2, F-LAN-1, F-LANa, FLANa
Species Human
Gene Type protein-coding
Description derlin 2
Other Description Der1-like domain family, member 2|carcinoma related|degradation in endoplasmic reticulum protein 2|derlin-2
Swissprots Q9GZP9 Q9Y3A7
Accessions EAW90329 Q9GZP9 AF132289 AAG43049 AF151859 AAD34096 AF208065 AAL14869 AF242523 AAF99603 AK024574 AK092218 BC010890 AAH10890 BG110482 BM675359 BU199049 CA425310 CN362881 CN362882 CR457202 CAG33483 HQ448209 ADQ32689 HY051246 XM_006721539 XP_006721602 XM_011523914 XP_011522216 XM_011523915 XP_011522217 XR_934033 XR_934034 NM_001304777 NP_001291706 NM_001304779 NP_001291708 NM_016041 NP_057125 NR_130905 NR_130906
Function Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation. {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}; Multi- pass membrane protein {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}.
Tissue Specificity Ubiquitous. Overexpressed in various hepatocarcinomas. {ECO:0000269|PubMed:11500051, ECO:0000269|PubMed:16449189}.
Top Pathways Protein processing in endoplasmic reticulum

DERL2-Over-expression-Lysate - LY10604a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag DERL2 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the DERL2 gene (Lane 2, Cat. #LY10604a).

DERL2 293 Cell Lysate - 402179 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Derlin-2 Overexpression Lysate (Native) - NBL1-09838 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Derlin-2 Overexpression Lysate (Adult Normal) [NBL1-09838] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Derlin-2.

DERL2 Over-expression Lysate Product - GWB-4EE1D5 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human DERL2 Knockdown Stable Cell Line - CSC-DC004231 from Creative biogene

Category Cell Line
Species Human
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