DERL2

Gene Symbol	DERL2
Entrez Gene	51009
Alt Symbol	CGI-101, DERtrin-2, F-LAN-1, F-LANa, FLANa
Species	Human
Gene Type	protein-coding
Description	derlin 2
Other Description	Der1-like domain family, member 2|carcinoma related|degradation in endoplasmic reticulum protein 2|derlin-2
Swissprots	Q9GZP9 Q9Y3A7
Accessions	EAW90329 Q9GZP9 AF132289 AAG43049 AF151859 AAD34096 AF208065 AAL14869 AF242523 AAF99603 AK024574 AK092218 BC010890 AAH10890 BG110482 BM675359 BU199049 CA425310 CN362881 CN362882 CR457202 CAG33483 HQ448209 ADQ32689 HY051246 XM_006721539 XP_006721602 XM_011523914 XP_011522216 XM_011523915 XP_011522217 XR_934033 XR_934034 NM_001304777 NP_001291706 NM_001304779 NP_001291708 NM_016041 NP_057125 NR_130905 NR_130906
Function	Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation. {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}; Multi- pass membrane protein {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}.
Tissue Specificity	Ubiquitous. Overexpressed in various hepatocarcinomas. {ECO:0000269|PubMed:11500051, ECO:0000269|PubMed:16449189}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DERL2 / Derlin-2 Antibody Blocking Peptide - LS-E9735 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DERL2 / Derlin-2 Antibody Blocking Peptide - LS-E23972 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DERL2 / Derlin-2 Antibody Blocking Peptide - LS-E6546 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DERL2-Antibody-C-term-Blocking-Peptide - BP8707b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DERL2 fusion protein - Ag14811 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

DERL2 fusion protein - ag14307 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DERL2, His-tagged - DERL2-11941H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human DERL2 - DERL2-984H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Derlin-2 - TP303046 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Derlin-2 Recombinant Protein Antigen - NBP2-47485PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Derlin-2 Recombinant Protein Antigen - NBP2-49231PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

DERL2 Peptide, Human - M34GP04231H from Creative Peptides Category Peptide Source Synthetic. Species Human

Derlin-2 (DERL2), Recombinant Protein - MBS7013713 from MyBioSource Category Protein Prices $1,055.00, $2,040.00, $3,250.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

Derlin-2 (DERL2), Recombinant Protein - MBS7013715 from MyBioSource Category Protein Prices $1,055.00, $2,040.00, $3,250.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Orangutan

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