ANAPC11

Gene Symbol ANAPC11
Entrez Gene 51529
Alt Symbol APC11, Apc11p, HSPC214
Species Human
Gene Type protein-coding
Description anaphase promoting complex subunit 11
Other Description APC11 anaphase promoting complex subunit 11 homolog|anaphase promoting complex subunit 11 (yeast APC11 homolog)|anaphase-promoting complex subunit 11|cyclosome subunit 11|hepatocellular carcinoma-associated RING finger protein
Swissprots A8MTT2 Q502X9 Q9BW64 Q9P0R2 B7ZW64 Q9NYG5
Accessions CAC24983 CAD61452 CAD61453 CAD61454 CAD61455 CAD61456 CAD61597 EAW89700 EAW89701 EAW89702 EAW89703 Q9NYG5 AA356010 AF151048 AAF36134 AF247565 AAF65816 AF247789 AAL95694 AI356704 AK091360 AK307214 AK308091 AW965775 BC000607 AAH00607 BC066308 AAH66308 BC095454 AAH95454 BC104641 AAI04642 BC171892 AAI71892 BC171898 AAI71898 BC171899 AAI71899 BC171900 AAI71900 BF435042 BF512771 BG707824 BM762129 BM845909 BU554167 BU556841 BY796995 CA335305 CB106395 DB501853 DB573049 HY067392 HY142453 NM_001002244 NP_001002244 NM_001002245 NP_001002245 NM_001002246 NP_001002246 NM_001002247 NP_001002247 NM_001002248 NP_001002248 NM_001002249 NP_001002249 NM_001289414 NP_001276343 NM_001289415 NP_001276344 NM_001289416 NP_001276345 NM_001289417 NP_001276346 NM_001289418 NP_001276347 NM_001289419 NP_001276348 NM_001289420 NP_001276349 NM_016476 NP_057560
Function Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. {ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11573242}. Nucleus {ECO:0000269|PubMed:11573242}.
Tissue Specificity Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte. {ECO:0000269|PubMed:11573242}.
Top Pathways Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection

APC11 (D1E7Q) Rabbit mAb - 14090 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1E7Q
Western blot analysis of extracts from various cell lines using APC11 (D1E7Q) Rabbit mAb.

APC11 (FL-84) - sc-20990 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

APC11 (V-20) - sc-21428 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
APC11 (V-20): sc-21428. Western blot analysis of APC11 expression in mouse heart tissue extract.

Anti-Apc11 antibody - ab133200 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded, formalin-fixed Human uterus tissue labelling Apc11 with ab133200 at 5 µg/ml, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Apc11 antibody - ab44708 from Abcam

Prices $370.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-Apc11 antibody - ab57158 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57158 Apc11 antibody at 1ug/ml.

Anti-Apc11 antibody - ab186055 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Apc11 antibody (ab186055) at 1 µg/ml + Cerebral Cortex lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-Apc11 antibody [3F5] - ab140511 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F5
Immunofluorescent analysis of COS7 cells transiently transfected with pCMV6-ENTRY Apc11, labelling Apc11 with ab140511 at 1/100 dilution.

Anti-Apc11 antibody [AX2.1] - ab78092 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone AX2.1

Anti-ANAPC11 / APC11 Antibody (C-Terminus) - LS-C19022 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ANAPC11 / APC11 Antibody (clone 1B4-1A4) - LS-C306242 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B4-1A4

Anti-ANAPC11 / APC11 Antibody (clone 1B5) - LS-C174743 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B5
Anti-ANAPC11 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ANAPC11.

Anti-ANAPC11 / APC11 Antibody (clone 3C4) - LS-C174746 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C4
IHC of paraffin-embedded Human Kidney tissue using anti-ANAPC11 mouse monoclonal antibody.

Anti-ANAPC11 / APC11 Antibody (clone 1B11) - LS-C338087 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B11
IHC of paraffin-embedded Human Kidney tissue using anti-ANAPC11 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-ANAPC11 / APC11 Antibody (clone 1A8) - LS-C338077 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A8
IHC of paraffin-embedded Human Kidney tissue using anti-ANAPC11 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-ANAPC11 / APC11 Antibody (clone 3F5) - LS-C174745 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F5
IHC of paraffin-embedded Human pancreas tissue using anti-ANAPC11 mouse monoclonal antibody.

Anti-ANAPC11 / APC11 Antibody (clone 1F2) - LS-C338088 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F2
IHC of paraffin-embedded Human pancreas tissue using anti-ANAPC11 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-ANAPC11 / APC11 Antibody (Internal) IHC-plus™ - LS-B6980 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ANAPC11 / APC11 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6980 concentration 5 ug/ml.

Apc11 Antibody - NBP1-90140 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Apc11 Antibody [NBP1-90140] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

Apc11 Antibody - NBP1-90139 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Apc11 Antibody [NBP1-90139] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

Apc11 Antibody - NBP1-78050 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Apc11 Antibody (1B4-1A4) - H00051529-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B4-1A4
Sandwich ELISA: Apc11 Antibody (1B4-1A4) [H00051529-M01] - Detection limit for recombinant GST tagged ANAPC11 is approximately 0.03ng/ml as a capture antibody.

APC11 Polyclonal Antibody - bs-12484R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

APC11 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12484R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

APC11 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12484R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Search more