ANAPC11

Gene Symbol	ANAPC11
Entrez Gene	51529
Alt Symbol	APC11, Apc11p, HSPC214
Species	Human
Gene Type	protein-coding
Description	anaphase promoting complex subunit 11
Other Description	APC11 anaphase promoting complex subunit 11 homolog|anaphase promoting complex subunit 11 (yeast APC11 homolog)|anaphase-promoting complex subunit 11|cyclosome subunit 11|hepatocellular carcinoma-associated RING finger protein
Swissprots	A8MTT2 Q502X9 Q9BW64 Q9P0R2 B7ZW64 Q9NYG5
Accessions	CAC24983 CAD61452 CAD61453 CAD61454 CAD61455 CAD61456 CAD61597 EAW89700 EAW89701 EAW89702 EAW89703 Q9NYG5 AA356010 AF151048 AAF36134 AF247565 AAF65816 AF247789 AAL95694 AI356704 AK091360 AK307214 AK308091 AW965775 BC000607 AAH00607 BC066308 AAH66308 BC095454 AAH95454 BC104641 AAI04642 BC171892 AAI71892 BC171898 AAI71898 BC171899 AAI71899 BC171900 AAI71900 BF435042 BF512771 BG707824 BM762129 BM845909 BU554167 BU556841 BY796995 CA335305 CB106395 DB501853 DB573049 HY067392 HY142453 NM_001002244 NP_001002244 NM_001002245 NP_001002245 NM_001002246 NP_001002246 NM_001002247 NP_001002247 NM_001002248 NP_001002248 NM_001002249 NP_001002249 NM_001289414 NP_001276343 NM_001289415 NP_001276344 NM_001289416 NP_001276345 NM_001289417 NP_001276346 NM_001289418 NP_001276347 NM_001289419 NP_001276348 NM_001289420 NP_001276349 NM_016476 NP_057560
Function	Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. {ECO:0000269|PubMed:11739784, ECO:0000269|PubMed:18485873}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11573242}. Nucleus {ECO:0000269|PubMed:11573242}.
Tissue Specificity	Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte. {ECO:0000269|PubMed:11573242}.
Top Pathways	Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® APC11 siRNA I - 14100 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

APC11 CRISPR/Cas9 KO Plasmid (h) - sc-405947 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

APC11 HDR Plasmid (h) - sc-405947-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

APC11 Double Nickase Plasmid (h) - sc-405947-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

APC11 Double Nickase Plasmid (h2) - sc-405947-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

APC11 CRISPR Activation Plasmid (h) - sc-405947-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

APC11 CRISPR Activation Plasmid (h2) - sc-405947-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

APC11 Lentiviral Activation Particles (h) - sc-405947-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

APC11 Lentiviral Activation Particles (h2) - sc-405947-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

APC11 siRNA (h) - sc-37534 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

APC11 shRNA Plasmid (h) - sc-37534-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

APC11 shRNA (h) Lentiviral Particles - sc-37534-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Apc11 RNAi - H00051529-R05 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Apc11 RNAi - H00051529-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Apc11 RNAi - H00051529-R06 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

Apc11 RNAi - H00051529-R04 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

Apc11 RNAi - H00051529-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Apc11 RNAi - H00051529-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU114151 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3137 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3137 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03079 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr03079

ANAPC11 siRNA (Human) - CRH9813 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Apc11 RNAi - H00051529-R07 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ANAPC11 - MBS8226848 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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